Amusia and its electrophysiological correlates in neurofibromatosis type 1
ABSTRACT Auditory processing deficits are common in people with neurofibromatosis type 1 (NF1) and they often report difficulties in musical performance. Objective: We investigated whether NF1 could be associated with amusia as well as with some impairment of primary auditory cortex activity. Meth...
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| Series: | Arquivos de Neuro-Psiquiatria |
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| author | Bruno Cézar Lage Cota João Gabriel Marques Fonseca Luiz Oswaldo Carneiro Rodrigues Nilton Alves de Rezende Pollyanna Barros Batista Vincent Michael Riccardi Luciana Macedo de Resende |
| author_facet | Bruno Cézar Lage Cota João Gabriel Marques Fonseca Luiz Oswaldo Carneiro Rodrigues Nilton Alves de Rezende Pollyanna Barros Batista Vincent Michael Riccardi Luciana Macedo de Resende |
| author_sort | Bruno Cézar Lage Cota |
| collection | DOAJ |
| description | ABSTRACT Auditory processing deficits are common in people with neurofibromatosis type 1 (NF1) and they often report difficulties in musical performance. Objective: We investigated whether NF1 could be associated with amusia as well as with some impairment of primary auditory cortex activity. Methods: Eighteen people with NF1 and 22 healthy volunteers, matched for age, sex and educational level, were evaluated with the Montreal Battery Evaluation of Amusia – short version. The integrity of cortical primary auditory processing areas was evaluated by evoked potential mismatch negativity. Results: Amusia was correlated with NF1 (p = 0.001, odds ratio = 42.0, confidence interval 4.5–39.6). Patients with NF1 exhibited a greater prevalence of amusia than healthy controls (67% vs. 4.5%) and difficulties in both melodic and temporal music perception. Worse performance on the Montreal Battery Evaluation of Amusia was correlated with a greater mismatch negativity latency in NF1 group. Conclusions: Amusia is a common feature in NF1 and may result from impairment of activity in primary auditory processing areas. |
| format | Article |
| id | doaj-art-be50c468b56e4ee9bf81e759547fb438 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-be50c468b56e4ee9bf81e759547fb4382025-08-20T03:23:01ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-422776528729510.1590/0004-282x20180031S0004-282X2018000500287Amusia and its electrophysiological correlates in neurofibromatosis type 1Bruno Cézar Lage CotaJoão Gabriel Marques FonsecaLuiz Oswaldo Carneiro RodriguesNilton Alves de RezendePollyanna Barros BatistaVincent Michael RiccardiLuciana Macedo de ResendeABSTRACT Auditory processing deficits are common in people with neurofibromatosis type 1 (NF1) and they often report difficulties in musical performance. Objective: We investigated whether NF1 could be associated with amusia as well as with some impairment of primary auditory cortex activity. Methods: Eighteen people with NF1 and 22 healthy volunteers, matched for age, sex and educational level, were evaluated with the Montreal Battery Evaluation of Amusia – short version. The integrity of cortical primary auditory processing areas was evaluated by evoked potential mismatch negativity. Results: Amusia was correlated with NF1 (p = 0.001, odds ratio = 42.0, confidence interval 4.5–39.6). Patients with NF1 exhibited a greater prevalence of amusia than healthy controls (67% vs. 4.5%) and difficulties in both melodic and temporal music perception. Worse performance on the Montreal Battery Evaluation of Amusia was correlated with a greater mismatch negativity latency in NF1 group. Conclusions: Amusia is a common feature in NF1 and may result from impairment of activity in primary auditory processing areas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500287&lng=en&tlng=enNeurofibromatose tipo 1músicapotenciais evocadostranstornos da percepção auditivanível de discriminação sonora |
| spellingShingle | Bruno Cézar Lage Cota João Gabriel Marques Fonseca Luiz Oswaldo Carneiro Rodrigues Nilton Alves de Rezende Pollyanna Barros Batista Vincent Michael Riccardi Luciana Macedo de Resende Amusia and its electrophysiological correlates in neurofibromatosis type 1 Arquivos de Neuro-Psiquiatria Neurofibromatose tipo 1 música potenciais evocados transtornos da percepção auditiva nível de discriminação sonora |
| title | Amusia and its electrophysiological correlates in neurofibromatosis type 1 |
| title_full | Amusia and its electrophysiological correlates in neurofibromatosis type 1 |
| title_fullStr | Amusia and its electrophysiological correlates in neurofibromatosis type 1 |
| title_full_unstemmed | Amusia and its electrophysiological correlates in neurofibromatosis type 1 |
| title_short | Amusia and its electrophysiological correlates in neurofibromatosis type 1 |
| title_sort | amusia and its electrophysiological correlates in neurofibromatosis type 1 |
| topic | Neurofibromatose tipo 1 música potenciais evocados transtornos da percepção auditiva nível de discriminação sonora |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500287&lng=en&tlng=en |
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