Different presentation of autoimmune hepatitis in children: Case series
Autoimmune hepatitis (AIH) is a disorder causing chronic hepatic inflammation. Its clinical presentation is highly variable from the affected child might have only biochemical evidence of liver dysfunction or present in hepatic failure. It is important to distinguish AIH from other forms of chronic...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-02-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1499_22 |
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| author | Qudsiya Ansari Vishal Sawant Alpana Santosh Kondekar |
| author_facet | Qudsiya Ansari Vishal Sawant Alpana Santosh Kondekar |
| author_sort | Qudsiya Ansari |
| collection | DOAJ |
| description | Autoimmune hepatitis (AIH) is a disorder causing chronic hepatic inflammation. Its clinical presentation is highly variable from the affected child might have only biochemical evidence of liver dysfunction or present in hepatic failure. It is important to distinguish AIH from other forms of chronic hepatitis because a high percentage of cases respond to immunosuppressive therapy. In this article, we describe the clinical presentation, biochemical and histological findings, treatment, and clinical outcome of the four children with AIH in a tertiary care center in Mumbai. Most patients with AIH have high levels of immunoglobulin. All four cases showed high serum Ig G levels and responded to oral prednisolone only. AIH should be excluded for all patients with symptoms or signs of prolonged, relapsing, or severe liver disease so that treatment can be promptly initiated and morbidity can be reduced. |
| format | Article |
| id | doaj-art-be4fb2121b884b56be12f056f986f4da |
| institution | OA Journals |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-be4fb2121b884b56be12f056f986f4da2025-08-20T02:13:44ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352023-02-0112240640910.4103/jfmpc.jfmpc_1499_22Different presentation of autoimmune hepatitis in children: Case seriesQudsiya AnsariVishal SawantAlpana Santosh KondekarAutoimmune hepatitis (AIH) is a disorder causing chronic hepatic inflammation. Its clinical presentation is highly variable from the affected child might have only biochemical evidence of liver dysfunction or present in hepatic failure. It is important to distinguish AIH from other forms of chronic hepatitis because a high percentage of cases respond to immunosuppressive therapy. In this article, we describe the clinical presentation, biochemical and histological findings, treatment, and clinical outcome of the four children with AIH in a tertiary care center in Mumbai. Most patients with AIH have high levels of immunoglobulin. All four cases showed high serum Ig G levels and responded to oral prednisolone only. AIH should be excluded for all patients with symptoms or signs of prolonged, relapsing, or severe liver disease so that treatment can be promptly initiated and morbidity can be reduced.https://journals.lww.com/10.4103/jfmpc.jfmpc_1499_22autoimmune hepatitishypergammaglobulinemialiver function tests |
| spellingShingle | Qudsiya Ansari Vishal Sawant Alpana Santosh Kondekar Different presentation of autoimmune hepatitis in children: Case series Journal of Family Medicine and Primary Care autoimmune hepatitis hypergammaglobulinemia liver function tests |
| title | Different presentation of autoimmune hepatitis in children: Case series |
| title_full | Different presentation of autoimmune hepatitis in children: Case series |
| title_fullStr | Different presentation of autoimmune hepatitis in children: Case series |
| title_full_unstemmed | Different presentation of autoimmune hepatitis in children: Case series |
| title_short | Different presentation of autoimmune hepatitis in children: Case series |
| title_sort | different presentation of autoimmune hepatitis in children case series |
| topic | autoimmune hepatitis hypergammaglobulinemia liver function tests |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_1499_22 |
| work_keys_str_mv | AT qudsiyaansari differentpresentationofautoimmunehepatitisinchildrencaseseries AT vishalsawant differentpresentationofautoimmunehepatitisinchildrencaseseries AT alpanasantoshkondekar differentpresentationofautoimmunehepatitisinchildrencaseseries |