Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a complex disease, in which local inflammatory stress results from both metabolic and hemodynamic derangements. Intercellular adhesion molecule 1 (ICAM-1) is an acute-phase protein marker of inflammation. In the recent years, clinical observations have reported that...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8305460 |
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| author | Xiuli Zhang Norhashimah Abu Seman Henrik Falhammar Kerstin Brismar Harvest F. Gu |
| author_facet | Xiuli Zhang Norhashimah Abu Seman Henrik Falhammar Kerstin Brismar Harvest F. Gu |
| author_sort | Xiuli Zhang |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is a complex disease, in which local inflammatory stress results from both metabolic and hemodynamic derangements. Intercellular adhesion molecule 1 (ICAM-1) is an acute-phase protein marker of inflammation. In the recent years, clinical observations have reported that increased serum/plasma ICAM-1 levels are positively correlated with albuminuria in the patients with type 1 (T1D) and type 2 diabetes (T2D). Genetic association studies have demonstrated that genetic polymorphisms, including SNP rs5498 (E469K, G/A), in the ICAM1 gene is associated with DKD. rs5498 is a nonsynonymous SNP and caused by substitution between E (Glu) and K (Lys) for ICAM-1 protein. In this review, we first summarized the genetic effects of ICAM1 E469K polymorphism in DKD and then demonstrated the possible changes of ICAM-1 protein crystal structures according to the genotypes of this polymorphism. Finally, we discussed the genetic effects of the ICAM1 E469K polymorphism and the biological role of increased circulating ICAM-1 protein and its formation changes in DKD. |
| format | Article |
| id | doaj-art-be4abf9163ec4ce4b41e701c18b62ea6 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-be4abf9163ec4ce4b41e701c18b62ea62025-08-20T02:18:35ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/83054608305460Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney DiseaseXiuli Zhang0Norhashimah Abu Seman1Henrik Falhammar2Kerstin Brismar3Harvest F. Gu4Department of Nephrology, The second People’s Hospital, Shenzhen, The first Affiliated Hospital of Shenzhen University, Guangdong 518000, ChinaCardiovascular, Diabetes and Nutrition Research Center, Institute for Medical Research, Kuala Lumpur 50588, MalaysiaRolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, SwedenRolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, SwedenCenter for Pathophysiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaDiabetic kidney disease (DKD) is a complex disease, in which local inflammatory stress results from both metabolic and hemodynamic derangements. Intercellular adhesion molecule 1 (ICAM-1) is an acute-phase protein marker of inflammation. In the recent years, clinical observations have reported that increased serum/plasma ICAM-1 levels are positively correlated with albuminuria in the patients with type 1 (T1D) and type 2 diabetes (T2D). Genetic association studies have demonstrated that genetic polymorphisms, including SNP rs5498 (E469K, G/A), in the ICAM1 gene is associated with DKD. rs5498 is a nonsynonymous SNP and caused by substitution between E (Glu) and K (Lys) for ICAM-1 protein. In this review, we first summarized the genetic effects of ICAM1 E469K polymorphism in DKD and then demonstrated the possible changes of ICAM-1 protein crystal structures according to the genotypes of this polymorphism. Finally, we discussed the genetic effects of the ICAM1 E469K polymorphism and the biological role of increased circulating ICAM-1 protein and its formation changes in DKD.http://dx.doi.org/10.1155/2020/8305460 |
| spellingShingle | Xiuli Zhang Norhashimah Abu Seman Henrik Falhammar Kerstin Brismar Harvest F. Gu Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease Journal of Diabetes Research |
| title | Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease |
| title_full | Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease |
| title_fullStr | Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease |
| title_full_unstemmed | Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease |
| title_short | Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease |
| title_sort | genetic and biological effects of icam 1 e469k polymorphism in diabetic kidney disease |
| url | http://dx.doi.org/10.1155/2020/8305460 |
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