The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis
Single studies attempting to associate ANP gene T2238C (rs5065) polymorphism with hypertension have so far reported inconclusive results. We therefore aimed to evaluate this association via a meta-analysis. Data on 7 studies with a total of 4068 subjects were available and analyzed using the random-...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/653698 |
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| author | Wenquan Niu |
| author_facet | Wenquan Niu |
| author_sort | Wenquan Niu |
| collection | DOAJ |
| description | Single studies attempting to associate ANP gene T2238C (rs5065) polymorphism with hypertension have so far reported inconclusive results. We therefore aimed to evaluate this association via a meta-analysis. Data on 7 studies with a total of 4068 subjects were available and analyzed using the random-effects model with assessment of heterogeneity and publication bias. Overall comparison of 2238C with 2238T yielded a 23% reduced, albeit nonsignificant, risk for hypertension (95% CI: 0.38–1.59; P=.485), while accompanying significant heterogeneity (I2=88.3%) and publication bias (P=.051). Subgroup analysis by study design demonstrated opposite associations between population-based (OR=0.33; 95% CI: 0.13–0.80; P=.015) and hospital-based studies (OR=1.15; 95% CI: 0.79–1.68; P=.454). Further meta-regression analysis exclusively indicated the significant influence of study design (P=.042) on heterogeneity. Taken together, these findings support the notion that carriers of 2238C allele were at moderate decreased risk of developing hypertension, whereas study design was identified as a potentially significant source of between-study heterogeneity. |
| format | Article |
| id | doaj-art-be4a64f2875c445ba08c450b65a9b0e4 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
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| series | International Journal of Hypertension |
| spelling | doaj-art-be4a64f2875c445ba08c450b65a9b0e42025-02-03T07:24:37ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/653698653698The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-AnalysisWenquan Niu0State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Vascular Biology, and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Second Road 197, Shanghai 200025, ChinaSingle studies attempting to associate ANP gene T2238C (rs5065) polymorphism with hypertension have so far reported inconclusive results. We therefore aimed to evaluate this association via a meta-analysis. Data on 7 studies with a total of 4068 subjects were available and analyzed using the random-effects model with assessment of heterogeneity and publication bias. Overall comparison of 2238C with 2238T yielded a 23% reduced, albeit nonsignificant, risk for hypertension (95% CI: 0.38–1.59; P=.485), while accompanying significant heterogeneity (I2=88.3%) and publication bias (P=.051). Subgroup analysis by study design demonstrated opposite associations between population-based (OR=0.33; 95% CI: 0.13–0.80; P=.015) and hospital-based studies (OR=1.15; 95% CI: 0.79–1.68; P=.454). Further meta-regression analysis exclusively indicated the significant influence of study design (P=.042) on heterogeneity. Taken together, these findings support the notion that carriers of 2238C allele were at moderate decreased risk of developing hypertension, whereas study design was identified as a potentially significant source of between-study heterogeneity.http://dx.doi.org/10.4061/2011/653698 |
| spellingShingle | Wenquan Niu The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis International Journal of Hypertension |
| title | The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis |
| title_full | The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis |
| title_fullStr | The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis |
| title_full_unstemmed | The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis |
| title_short | The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis |
| title_sort | relationship between natriuretic peptide precursor a gene t2238c polymorphism and hypertension a meta analysis |
| url | http://dx.doi.org/10.4061/2011/653698 |
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