The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of Atherosclerosis
Introduction. Few studies have examined the association between the PR interval (PRi) and subclinical cardiovascular disease measures. Methods and Results. The Multiethnic Study of Atherosclerosis (MESA) is a population-based study of 6814 men and women aged 45–84 years without clinical cardiovascul...
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Wiley
2015-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/193698 |
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| author | Michael P. Husby Elsayed Z. Soliman Jeffrey J. Goldberger Kiang Liu Don Lloyd-Jones Ramon Durazo-Arvizu Holly Kramer |
| author_facet | Michael P. Husby Elsayed Z. Soliman Jeffrey J. Goldberger Kiang Liu Don Lloyd-Jones Ramon Durazo-Arvizu Holly Kramer |
| author_sort | Michael P. Husby |
| collection | DOAJ |
| description | Introduction. Few studies have examined the association between the PR interval (PRi) and subclinical cardiovascular disease measures. Methods and Results. The Multiethnic Study of Atherosclerosis (MESA) is a population-based study of 6814 men and women aged 45–84 years without clinical cardiovascular disease and 4962 had complete baseline data on cardiac magnetic resonance imaging measures of LV dimension and ejection fraction and surface electrocardiogram. Linear regression models were constructed to determine the adjusted association between the PRi and measures of LV stroke volume, LV mass, LV end-systolic and end-diastolic volumes, and ejection fraction. Overall, mean age was 61.5 years, and 47.6% were male and race/ethnicity was white in 39.1%, Chinese in 13.1%, African-American in 25.7%, and Hispanic in 22.2%. The PRi ranged from 88 to 308 ms with a median value of 162 ms. As a continuous variable, every standard deviation unit (25 ms) increment in PRi was associated with a 2.00 mL (95% CI 1.52, 2.48) higher stroke volume, a 3.08 g (95% CI 2.30, 3.86) higher LV mass, a 1.36 g/m2 (95% CI 0.96, 1.76) higher LV mass index, and 1.31 mL (95% CI 0.88, 1.73) higher end-systolic and 3.31 mL (95% CI 2.58, 4.03) higher end-diastolic volumes after adjustment for all covariates. No significant association was noted between the PRi and LV ejection fraction. Conclusions. A prolonged PRi is associated with LV measures and may in part explain the link between a prolonged PRi and cardiovascular outcomes. |
| format | Article |
| id | doaj-art-be4950bc053245f8a6d8d1e774f9c1e7 |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-be4950bc053245f8a6d8d1e774f9c1e72025-08-20T02:18:35ZengWileyCardiology Research and Practice2090-80162090-05972015-01-01201510.1155/2015/193698193698The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of AtherosclerosisMichael P. Husby0Elsayed Z. Soliman1Jeffrey J. Goldberger2Kiang Liu3Don Lloyd-Jones4Ramon Durazo-Arvizu5Holly Kramer6Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USADepartment of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USADepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USADepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USAIntroduction. Few studies have examined the association between the PR interval (PRi) and subclinical cardiovascular disease measures. Methods and Results. The Multiethnic Study of Atherosclerosis (MESA) is a population-based study of 6814 men and women aged 45–84 years without clinical cardiovascular disease and 4962 had complete baseline data on cardiac magnetic resonance imaging measures of LV dimension and ejection fraction and surface electrocardiogram. Linear regression models were constructed to determine the adjusted association between the PRi and measures of LV stroke volume, LV mass, LV end-systolic and end-diastolic volumes, and ejection fraction. Overall, mean age was 61.5 years, and 47.6% were male and race/ethnicity was white in 39.1%, Chinese in 13.1%, African-American in 25.7%, and Hispanic in 22.2%. The PRi ranged from 88 to 308 ms with a median value of 162 ms. As a continuous variable, every standard deviation unit (25 ms) increment in PRi was associated with a 2.00 mL (95% CI 1.52, 2.48) higher stroke volume, a 3.08 g (95% CI 2.30, 3.86) higher LV mass, a 1.36 g/m2 (95% CI 0.96, 1.76) higher LV mass index, and 1.31 mL (95% CI 0.88, 1.73) higher end-systolic and 3.31 mL (95% CI 2.58, 4.03) higher end-diastolic volumes after adjustment for all covariates. No significant association was noted between the PRi and LV ejection fraction. Conclusions. A prolonged PRi is associated with LV measures and may in part explain the link between a prolonged PRi and cardiovascular outcomes.http://dx.doi.org/10.1155/2015/193698 |
| spellingShingle | Michael P. Husby Elsayed Z. Soliman Jeffrey J. Goldberger Kiang Liu Don Lloyd-Jones Ramon Durazo-Arvizu Holly Kramer The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of Atherosclerosis Cardiology Research and Practice |
| title | The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of Atherosclerosis |
| title_full | The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of Atherosclerosis |
| title_fullStr | The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of Atherosclerosis |
| title_full_unstemmed | The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of Atherosclerosis |
| title_short | The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of Atherosclerosis |
| title_sort | association between the pr interval and left ventricular measurements in the multiethnic study of atherosclerosis |
| url | http://dx.doi.org/10.1155/2015/193698 |
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