Advances in cfDNA research for pregnancy-related diseases
Circulating cell-free DNA (cfDNA) comprises extracellular DNA fragments released into bodily fluids through cellular processes such as apoptosis, necrosis, and active secretion. Alterations in cfDNA concentration, fragmentation patterns, and molecular characteristics under physiological and patholog...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1600532/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849340765349609472 |
|---|---|
| author | Yimei Meng Yimei Meng Yu Yan Xiaoshan Yue Yan Li Yanxiang Mo |
| author_facet | Yimei Meng Yimei Meng Yu Yan Xiaoshan Yue Yan Li Yanxiang Mo |
| author_sort | Yimei Meng |
| collection | DOAJ |
| description | Circulating cell-free DNA (cfDNA) comprises extracellular DNA fragments released into bodily fluids through cellular processes such as apoptosis, necrosis, and active secretion. Alterations in cfDNA concentration, fragmentation patterns, and molecular characteristics under physiological and pathological conditions, including pregnancy-related disorders, have established its value as a minimally invasive biomarker for early disease detection and clinical monitoring. Due to the availability of non- or minimally-invasive and scalable detection platforms with high sensitivity and specificity, cfDNA has emerged as a powerful tool in maternal-fetal medicine. This review provides a comprehensive overview of recent advances in cfDNA research, with an emphasis on its applications in pregnancy-related disorders. We elucidate the underlying biological mechanisms, current diagnostic and prognostic uses, analytical technologies, and the key challenges and future directions for clinical translation. |
| format | Article |
| id | doaj-art-be46d82aa6b6406f95143e34b3bb1fe3 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-be46d82aa6b6406f95143e34b3bb1fe32025-08-20T03:43:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-08-011310.3389/fcell.2025.16005321600532Advances in cfDNA research for pregnancy-related diseasesYimei Meng0Yimei Meng1Yu Yan2Xiaoshan Yue3Yan Li4Yanxiang Mo5Department of Obstetrics, Obstetrics and Gynecology Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Gynecological Oncology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Obstetrics, Obstetrics and Gynecology Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Obstetrics, Obstetrics and Gynecology Center, The First Hospital of Jilin University, Changchun, ChinaCirculating cell-free DNA (cfDNA) comprises extracellular DNA fragments released into bodily fluids through cellular processes such as apoptosis, necrosis, and active secretion. Alterations in cfDNA concentration, fragmentation patterns, and molecular characteristics under physiological and pathological conditions, including pregnancy-related disorders, have established its value as a minimally invasive biomarker for early disease detection and clinical monitoring. Due to the availability of non- or minimally-invasive and scalable detection platforms with high sensitivity and specificity, cfDNA has emerged as a powerful tool in maternal-fetal medicine. This review provides a comprehensive overview of recent advances in cfDNA research, with an emphasis on its applications in pregnancy-related disorders. We elucidate the underlying biological mechanisms, current diagnostic and prognostic uses, analytical technologies, and the key challenges and future directions for clinical translation.https://www.frontiersin.org/articles/10.3389/fcell.2025.1600532/fullcell-free DNA (cfDNA)pregnancy-related disordersnon-invasive biomarkerspreeclampsiagestational diabetes mellitus |
| spellingShingle | Yimei Meng Yimei Meng Yu Yan Xiaoshan Yue Yan Li Yanxiang Mo Advances in cfDNA research for pregnancy-related diseases Frontiers in Cell and Developmental Biology cell-free DNA (cfDNA) pregnancy-related disorders non-invasive biomarkers preeclampsia gestational diabetes mellitus |
| title | Advances in cfDNA research for pregnancy-related diseases |
| title_full | Advances in cfDNA research for pregnancy-related diseases |
| title_fullStr | Advances in cfDNA research for pregnancy-related diseases |
| title_full_unstemmed | Advances in cfDNA research for pregnancy-related diseases |
| title_short | Advances in cfDNA research for pregnancy-related diseases |
| title_sort | advances in cfdna research for pregnancy related diseases |
| topic | cell-free DNA (cfDNA) pregnancy-related disorders non-invasive biomarkers preeclampsia gestational diabetes mellitus |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1600532/full |
| work_keys_str_mv | AT yimeimeng advancesincfdnaresearchforpregnancyrelateddiseases AT yimeimeng advancesincfdnaresearchforpregnancyrelateddiseases AT yuyan advancesincfdnaresearchforpregnancyrelateddiseases AT xiaoshanyue advancesincfdnaresearchforpregnancyrelateddiseases AT yanli advancesincfdnaresearchforpregnancyrelateddiseases AT yanxiangmo advancesincfdnaresearchforpregnancyrelateddiseases |