ADATs: roles in tRNA editing and relevance to disease
Transfer RNAs (tRNAs) play central roles in protein biosynthesis. Post-transcriptional RNA modifications affect tRNA function and stability. Among these modifications, RNA editing is a widespread RNA modification in three domains of life. P...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-07-01
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| Series: | Acta Biochimica et Biophysica Sinica |
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| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024125 |
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| author | Mao Xue-Ling Eriani Gilbert Zhou Xiao-Long |
| author_facet | Mao Xue-Ling Eriani Gilbert Zhou Xiao-Long |
| author_sort | Mao Xue-Ling |
| collection | DOAJ |
| description | Transfer RNAs (tRNAs) play central roles in protein biosynthesis. Post-transcriptional RNA modifications affect tRNA function and stability. Among these modifications, RNA editing is a widespread RNA modification in three domains of life. Proteins of the adenosine deaminase acting on tRNA (ADAT) family were discovered more than <sc>20 years</sc> ago. They catalyze the deamination of adenosine to inosine (A-to-I) or cytidine to uridine (C-to-U) during tRNA maturation. The most studied example is the TadA- or ADAT2/3-mediated A-to-I conversion of the tRNA wobble position in the anticodon of prokaryotic or eukaryotic tRNAs, respectively. This review provides detailed information on A-to-I and C-to-U editing of tRNAs in different domains of life, presents recent new findings on ADATs for DNA editing, and finally comments on the association of mutations in the ADAT3 gene with intellectual disability. |
| format | Article |
| id | doaj-art-be43091886b945beb8196d44f278a57b |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-be43091886b945beb8196d44f278a57b2025-01-24T00:56:45ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-07-0157738310.3724/abbs.202412520d259ccADATs: roles in tRNA editing and relevance to diseaseMao Xue-Ling0Eriani Gilbert1Zhou Xiao-Long2["Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"]["Architecture et Réactivité de l′ARN, Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg, 2 allée Konrad Roentgen, 67084 Strasbourg, France"]["Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China"]Transfer RNAs (tRNAs) play central roles in protein biosynthesis. Post-transcriptional RNA modifications affect tRNA function and stability. Among these modifications, RNA editing is a widespread RNA modification in three domains of life. Proteins of the adenosine deaminase acting on tRNA (ADAT) family were discovered more than <sc>20 years</sc> ago. They catalyze the deamination of adenosine to inosine (A-to-I) or cytidine to uridine (C-to-U) during tRNA maturation. The most studied example is the TadA- or ADAT2/3-mediated A-to-I conversion of the tRNA wobble position in the anticodon of prokaryotic or eukaryotic tRNAs, respectively. This review provides detailed information on A-to-I and C-to-U editing of tRNAs in different domains of life, presents recent new findings on ADATs for DNA editing, and finally comments on the association of mutations in the ADAT3 gene with intellectual disability.https://www.sciengine.com/doi/10.3724/abbs.2024125tRNA editingdeaminaseTadAADAT2/3 |
| spellingShingle | Mao Xue-Ling Eriani Gilbert Zhou Xiao-Long ADATs: roles in tRNA editing and relevance to disease Acta Biochimica et Biophysica Sinica tRNA editing deaminase TadA ADAT2/3 |
| title | ADATs: roles in tRNA editing and relevance to disease |
| title_full | ADATs: roles in tRNA editing and relevance to disease |
| title_fullStr | ADATs: roles in tRNA editing and relevance to disease |
| title_full_unstemmed | ADATs: roles in tRNA editing and relevance to disease |
| title_short | ADATs: roles in tRNA editing and relevance to disease |
| title_sort | adats roles in trna editing and relevance to disease |
| topic | tRNA editing deaminase TadA ADAT2/3 |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024125 |
| work_keys_str_mv | AT maoxueling adatsrolesintrnaeditingandrelevancetodisease AT erianigilbert adatsrolesintrnaeditingandrelevancetodisease AT zhouxiaolong adatsrolesintrnaeditingandrelevancetodisease |