Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.

Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.

The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of immune correlates of protection represents a major barrier to the design of vaccines and therapeutic approaches to prevent infection or limit di...

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Main Authors: Jessica B Graham, Jessica L Swarts, Sarah R Leist, Alexandra Schäfer, Vineet D Menachery, Lisa E Gralinski, Sophia Jeng, Darla R Miller, Michael A Mooney, Shannon K McWeeney, Martin T Ferris, Fernando Pardo-Manuel de Villena, Mark T Heise, Ralph S Baric, Jennifer M Lund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009287&type=printable
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