Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test
Abstract In amblyopia, abnormal binocular interactions lead to an overwhelming dominance of one eye. One mechanism implied in this imbalance is the suppression between the inputs from the two eyes. This interocular suppression involves two components: an overlay suppression and a surround suppressio...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-82899-2 |
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| author | Alexandre Reynaud Marie-Céline Lorenzini Robert K. Koenekoop Robert F. Hess Alex S. Baldwin |
| author_facet | Alexandre Reynaud Marie-Céline Lorenzini Robert K. Koenekoop Robert F. Hess Alex S. Baldwin |
| author_sort | Alexandre Reynaud |
| collection | DOAJ |
| description | Abstract In amblyopia, abnormal binocular interactions lead to an overwhelming dominance of one eye. One mechanism implied in this imbalance is the suppression between the inputs from the two eyes. This interocular suppression involves two components: an overlay suppression and a surround suppression. Here, we propose a new method for measuring surround suppression which has been demonstrated in both strabismic and anisometropic amblyopes, based on a novel interocular contrast scaling task, suitable for use as a clinical tool. We compare the results obtained with this method against those from another method designed to measure overlay suppression: the Dichoptic Letter Test. We find a strong correlation between the results obtained with the two methods. Additionally, we observe strong correlations between the imbalance measured with the two tests and visual acuity and stereopsis. Altogether this suggests that amblyopic suppression is spatially broad and has direct relevance in global vision. So our new method is a relevant, clinically suitable tool to track the disease state in amblyopia. |
| format | Article |
| id | doaj-art-be3d370a55014c6598b543963223c287 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-be3d370a55014c6598b543963223c2872025-01-05T12:18:56ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-82899-2Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters testAlexandre Reynaud0Marie-Céline Lorenzini1Robert K. Koenekoop2Robert F. Hess3Alex S. Baldwin4Department Ophthalmology and Visual Sciences, McGill Vision Research, McGill UniversityBRaIN Program, Research Institute of the McGill University Health CenterDepartment of Pediatric Surgery, Human Genetics and Ophthalmology, Montreal Children’s Hospital, McGill UniversityDepartment Ophthalmology and Visual Sciences, McGill Vision Research, McGill UniversityDepartment Ophthalmology and Visual Sciences, McGill Vision Research, McGill UniversityAbstract In amblyopia, abnormal binocular interactions lead to an overwhelming dominance of one eye. One mechanism implied in this imbalance is the suppression between the inputs from the two eyes. This interocular suppression involves two components: an overlay suppression and a surround suppression. Here, we propose a new method for measuring surround suppression which has been demonstrated in both strabismic and anisometropic amblyopes, based on a novel interocular contrast scaling task, suitable for use as a clinical tool. We compare the results obtained with this method against those from another method designed to measure overlay suppression: the Dichoptic Letter Test. We find a strong correlation between the results obtained with the two methods. Additionally, we observe strong correlations between the imbalance measured with the two tests and visual acuity and stereopsis. Altogether this suggests that amblyopic suppression is spatially broad and has direct relevance in global vision. So our new method is a relevant, clinically suitable tool to track the disease state in amblyopia.https://doi.org/10.1038/s41598-024-82899-2 |
| spellingShingle | Alexandre Reynaud Marie-Céline Lorenzini Robert K. Koenekoop Robert F. Hess Alex S. Baldwin Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test Scientific Reports |
| title | Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test |
| title_full | Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test |
| title_fullStr | Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test |
| title_full_unstemmed | Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test |
| title_short | Amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test |
| title_sort | amblyopic binocular imbalance quantified by the dichoptic contrast ordering test and dichoptic letters test |
| url | https://doi.org/10.1038/s41598-024-82899-2 |
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