Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration
AIM: To compare the differences of choroidal neovascularization (CNV) measurements between swept-source and spectral-domain optical coherence tomography angiography (SS-OCTA and SD-OCTA) in neovascular age-related macular degeneration (nAMD) and the imaging reliability of the two devices. METHODS: P...
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-11-01
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| author | Ji-Xian Ma Zhuo-Yi Zhang Rong Di Jia-Jie Yang Si-Wen Tian Ya-Zhou Qin Wan-Hu Zhang Jian-Qin Lei Qiu-Ping Liu Jing-Ming Li |
| author_facet | Ji-Xian Ma Zhuo-Yi Zhang Rong Di Jia-Jie Yang Si-Wen Tian Ya-Zhou Qin Wan-Hu Zhang Jian-Qin Lei Qiu-Ping Liu Jing-Ming Li |
| author_sort | Ji-Xian Ma |
| collection | DOAJ |
| description | AIM: To compare the differences of choroidal neovascularization (CNV) measurements between swept-source and spectral-domain optical coherence tomography angiography (SS-OCTA and SD-OCTA) in neovascular age-related macular degeneration (nAMD) and the imaging reliability of the two devices. METHODS: Prospective comparative study. SS-OCTA and SD-OCTA were used to scan the same eye with the modes of 3×3 and 6×6 mm2 centered on the neovascularization. Only qualified images were chosen and the border of CNV was manually delineated by two graders independently. The area of CNV (ACNV), vascular perfusion density (PD), and vessel length density (VLD) within the delineation were calculated using Image J. The differences of CNV measurements between the two OCTA devices were compared using Bland-Altman analysis. The agreement between the two graders on the measurements of each device was compared using the intraclass correlation coefficient (ICC). RESULTS: A total of 18 patients (22 eyes) with nAMD were included. The measurements of ACNV, PD, and VLD were 7.247±4.586 and 4.901±3.741 mm2, 43.202±9.636 and 34.904±10.489, 6.339±1.228 and 5.908±1.741 mm-1 for SS-OCTA and SD-OCTA, respectively. The differences between the two devices were 2.346±3.030 mm2 (Z= -3.782, P<0.0001), 8.298±14.160 (Z=-2.419, P=0.016), and 0.431±2.114 mm-1 (Z=-0.828, P=0.408) for ACNV, PD and VLD, respectively. The ICC between two graders were 0.893 (P<0.001), 0.902 (P<0.001), 0.885 (P<0.001) for ACNV, PD, VLD in SS-OCTA, and 0.971 (P<0.001), 0.976 (P<0.001), 0.973 (P<0.001) in SD-OCTA, respectively. CONCLUSION: Both OCTA devices have high imaging reliability. Compared with SD-OCTA, SS-OCTA has a larger ACNV measurements, but doesn't show better resolution of internal vessels of CNV and well signal strength. |
| format | Article |
| id | doaj-art-be38beab846c41dbb6f4e71fb070ce5a |
| institution | OA Journals |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | International Journal of Ophthalmology |
| spelling | doaj-art-be38beab846c41dbb6f4e71fb070ce5a2025-08-20T02:09:48ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982024-11-0117112067207310.18240/ijo.2024.11.1320241113Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degenerationJi-Xian Ma0Zhuo-Yi Zhang1Rong Di2Jia-Jie Yang3Si-Wen Tian4Ya-Zhou Qin5Wan-Hu Zhang6Jian-Qin Lei7Qiu-Ping Liu8Jing-Ming Li9Jing-Ming Li. Department of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China. jingming_li@126.comDepartment of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, ChinaAffiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaAffiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, ChinaDepartment of Ophthalmology, First Affiliated Hospital of Nanhua University, Hengyang 421005, Hunan Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, ChinaAIM: To compare the differences of choroidal neovascularization (CNV) measurements between swept-source and spectral-domain optical coherence tomography angiography (SS-OCTA and SD-OCTA) in neovascular age-related macular degeneration (nAMD) and the imaging reliability of the two devices. METHODS: Prospective comparative study. SS-OCTA and SD-OCTA were used to scan the same eye with the modes of 3×3 and 6×6 mm2 centered on the neovascularization. Only qualified images were chosen and the border of CNV was manually delineated by two graders independently. The area of CNV (ACNV), vascular perfusion density (PD), and vessel length density (VLD) within the delineation were calculated using Image J. The differences of CNV measurements between the two OCTA devices were compared using Bland-Altman analysis. The agreement between the two graders on the measurements of each device was compared using the intraclass correlation coefficient (ICC). RESULTS: A total of 18 patients (22 eyes) with nAMD were included. The measurements of ACNV, PD, and VLD were 7.247±4.586 and 4.901±3.741 mm2, 43.202±9.636 and 34.904±10.489, 6.339±1.228 and 5.908±1.741 mm-1 for SS-OCTA and SD-OCTA, respectively. The differences between the two devices were 2.346±3.030 mm2 (Z= -3.782, P<0.0001), 8.298±14.160 (Z=-2.419, P=0.016), and 0.431±2.114 mm-1 (Z=-0.828, P=0.408) for ACNV, PD and VLD, respectively. The ICC between two graders were 0.893 (P<0.001), 0.902 (P<0.001), 0.885 (P<0.001) for ACNV, PD, VLD in SS-OCTA, and 0.971 (P<0.001), 0.976 (P<0.001), 0.973 (P<0.001) in SD-OCTA, respectively. CONCLUSION: Both OCTA devices have high imaging reliability. Compared with SD-OCTA, SS-OCTA has a larger ACNV measurements, but doesn't show better resolution of internal vessels of CNV and well signal strength.http://ies.ijo.cn/en_publish/2024/11/20241113.pdfneovascular age-related macular degenerationswept-sourcespectral-domainoptical coherence tomography angiography |
| spellingShingle | Ji-Xian Ma Zhuo-Yi Zhang Rong Di Jia-Jie Yang Si-Wen Tian Ya-Zhou Qin Wan-Hu Zhang Jian-Qin Lei Qiu-Ping Liu Jing-Ming Li Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration International Journal of Ophthalmology neovascular age-related macular degeneration swept-source spectral-domain optical coherence tomography angiography |
| title | Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration |
| title_full | Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration |
| title_fullStr | Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration |
| title_full_unstemmed | Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration |
| title_short | Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration |
| title_sort | comparative study between swept source and spectral domain octa for imaging of choroidal neovascularization in age related macular degeneration |
| topic | neovascular age-related macular degeneration swept-source spectral-domain optical coherence tomography angiography |
| url | http://ies.ijo.cn/en_publish/2024/11/20241113.pdf |
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