Case Report: Adrenocortical adenoma harboring atypical subclinical Cushing’s syndrome with dehydroepiandrosterone sulfate transferase and cytochrome b5 expression in tumor cells

Case Report: Adrenocortical adenoma harboring atypical subclinical Cushing’s syndrome with dehydroepiandrosterone sulfate transferase and cytochrome b5 expression in tumor cells

Subclinical Cushing’s syndrome (SCS) is frequently encountered during the clinical evaluation of adrenal incidentalomas and is typically associated with reduced levels of serum dehydroepiandrosterone sulfate (DHEA-S). Cytochrome b5 is a component of the electron transfer system that enhances the act...

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Main Authors: Ichiro Abe, Yuto Yamazaki, Ayuko Higashi, Kentaro Ochi, Keita Kubo, Yuya Fujita, Kaori Takeshita, Toshiaki Wada, Ryo Mitsuoka, Yo Yamashita, Ryoko Yoshida, Tamotsu Kato, Tadachika Kudo, Shigero Miyajima, Tatsu Ishii, Satoshi Nimura, Takashi Suzuki, Hironobu Sasano, Kunihisa Kobayashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
subclinical Cushing’s syndrome
hypercortisonemia
dehydroepiandrosterone
cytochrome b5
electron transfer system
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1624396/full
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