THERAPEUTIC ROLE OF NATURAL AGENTS IN BETA THALASSEMIA: A REVIEW
Beta (?) thalassemia is a genetic disease caused by either reduced production or due to complete absence of beta globin chains. It is characterized by dyserythropoiesis which leads to the development of early erythroid precursor cells into immature erythroblasts. Patients with high level of fetal ha...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1686 |
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| Summary: | Beta (?) thalassemia is a genetic disease caused by either reduced production or due to complete absence of beta globin chains. It is characterized by dyserythropoiesis which leads to the development of early erythroid precursor cells into immature erythroblasts. Patients with high level of fetal haemoglobin (HbF) develop less severe symptoms and survive normally. Therefore, augmentation of the level of HbF has been an effective therapeutic approach for patients of ?-thalassemia. Natural pharmacological agents have been used to stimulate the HbF level in patients suffering from this deleterious disease. This is an efficient way to treat ?-thalassemia as it also provides better correlation between in vivo and in vitro synthesis of beta globin chains in patients. Being economic, it is also affordable for the patients of developing countries. This article reports some natural compounds of plant origin having therapeutic role for inducing HbF level in ?-thalassemic patients. |
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| ISSN: | 2035-3006 |