Safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B)
Abstract The food enzyme triacylglycerol lipase (triacylglycerol acylhydrolase; EC 3.1.1.3) is produced with the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) by Amano Enzyme Inc. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this fo...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2025.9223 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576069198151680 |
|---|---|
| author | EFSA Panel on Food Enzymes (FEZ) Holger Zorn José Manuel Barat Baviera Claudia Bolognesi Francesco Catania Gabriele Gadermaier Ralf Greiner Baltasar Mayo Alicja Mortensen Yrjö Henrik Roos Marize L. M. Solano Monika Sramkova Henk Van Loveren Laurence Vernis Roos Anna deNijs Magdalena Andryszkiewicz Daniele Cavanna Yi Liu |
| author_facet | EFSA Panel on Food Enzymes (FEZ) Holger Zorn José Manuel Barat Baviera Claudia Bolognesi Francesco Catania Gabriele Gadermaier Ralf Greiner Baltasar Mayo Alicja Mortensen Yrjö Henrik Roos Marize L. M. Solano Monika Sramkova Henk Van Loveren Laurence Vernis Roos Anna deNijs Magdalena Andryszkiewicz Daniele Cavanna Yi Liu |
| author_sort | EFSA Panel on Food Enzymes (FEZ) |
| collection | DOAJ |
| description | Abstract The food enzyme triacylglycerol lipase (triacylglycerol acylhydrolase; EC 3.1.1.3) is produced with the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) by Amano Enzyme Inc. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in six food manufacturing processes. Subsequently, the applicant has requested to revise the use levels for three food manufacturing processes. In this assessment, EFSA updated the dietary exposure assessment of this food enzyme when used in six food manufacturing processes at the revised use levels. As the food enzyme–total organic solids (TOS) are removed from the final foods in one food manufacturing process, the dietary exposure to the food enzyme–TOS was estimated for the remaining five processes. It was calculated to be up to 0.220 mg TOS/kg body weight (bw) per day in European populations. Based on the new data, the revised exposure estimation and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use. |
| format | Article |
| id | doaj-art-be350543ba7f47bdb752259cd1579893 |
| institution | Kabale University |
| issn | 1831-4732 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-be350543ba7f47bdb752259cd15798932025-01-31T12:06:04ZengWileyEFSA Journal1831-47322025-01-01231n/an/a10.2903/j.efsa.2025.9223Safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B)EFSA Panel on Food Enzymes (FEZ)Holger ZornJosé Manuel Barat BavieraClaudia BolognesiFrancesco CataniaGabriele GadermaierRalf GreinerBaltasar MayoAlicja MortensenYrjö Henrik RoosMarize L. M. SolanoMonika SramkovaHenk Van LoverenLaurence VernisRoos Anna deNijsMagdalena AndryszkiewiczDaniele CavannaYi LiuAbstract The food enzyme triacylglycerol lipase (triacylglycerol acylhydrolase; EC 3.1.1.3) is produced with the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) by Amano Enzyme Inc. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in six food manufacturing processes. Subsequently, the applicant has requested to revise the use levels for three food manufacturing processes. In this assessment, EFSA updated the dietary exposure assessment of this food enzyme when used in six food manufacturing processes at the revised use levels. As the food enzyme–total organic solids (TOS) are removed from the final foods in one food manufacturing process, the dietary exposure to the food enzyme–TOS was estimated for the remaining five processes. It was calculated to be up to 0.220 mg TOS/kg body weight (bw) per day in European populations. Based on the new data, the revised exposure estimation and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.https://doi.org/10.2903/j.efsa.2025.9223EC 3.1.1.3EFSA‐Q‐2014‐00113EFSA‐Q‐2023‐00373food enzymeLimtongozyma cylindraceanon‐genetically modified organism |
| spellingShingle | EFSA Panel on Food Enzymes (FEZ) Holger Zorn José Manuel Barat Baviera Claudia Bolognesi Francesco Catania Gabriele Gadermaier Ralf Greiner Baltasar Mayo Alicja Mortensen Yrjö Henrik Roos Marize L. M. Solano Monika Sramkova Henk Van Loveren Laurence Vernis Roos Anna deNijs Magdalena Andryszkiewicz Daniele Cavanna Yi Liu Safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) EFSA Journal EC 3.1.1.3 EFSA‐Q‐2014‐00113 EFSA‐Q‐2023‐00373 food enzyme Limtongozyma cylindracea non‐genetically modified organism |
| title | Safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) |
| title_full | Safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) |
| title_fullStr | Safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) |
| title_full_unstemmed | Safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) |
| title_short | Safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non‐genetically modified Limtongozyma cylindracea strain AE‐LAYH (B) |
| title_sort | safety evaluation of changed use levels of the food enzyme triacylglycerol lipase from the non genetically modified limtongozyma cylindracea strain ae layh b |
| topic | EC 3.1.1.3 EFSA‐Q‐2014‐00113 EFSA‐Q‐2023‐00373 food enzyme Limtongozyma cylindracea non‐genetically modified organism |
| url | https://doi.org/10.2903/j.efsa.2025.9223 |
| work_keys_str_mv | AT efsapanelonfoodenzymesfez safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT holgerzorn safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT josemanuelbaratbaviera safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT claudiabolognesi safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT francescocatania safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT gabrielegadermaier safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT ralfgreiner safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT baltasarmayo safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT alicjamortensen safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT yrjohenrikroos safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT marizelmsolano safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT monikasramkova safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT henkvanloveren safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT laurencevernis safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT roosannadenijs safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT magdalenaandryszkiewicz safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT danielecavanna safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb AT yiliu safetyevaluationofchangeduselevelsofthefoodenzymetriacylglycerollipasefromthenongeneticallymodifiedlimtongozymacylindraceastrainaelayhb |