The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An Overview
Type 2 diabetes (T2D) is one of the scourges of modern times, with many millions of people affected by the disease. Diabetes occurs most frequently in those who are overweight or obese. However, not all overweight and obese persons develop diabetes, and there are those who develop the disease who ar...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.6064/2012/482186 |
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| author | Paul W. Franks |
| author_facet | Paul W. Franks |
| author_sort | Paul W. Franks |
| collection | DOAJ |
| description | Type 2 diabetes (T2D) is one of the scourges of modern times, with many millions of people affected by the disease. Diabetes occurs most frequently in those who are overweight or obese. However, not all overweight and obese persons develop diabetes, and there are those who develop the disease who are lean and physically active. Certain ethnicities, especially indigenous populations, are at considerably higher risk of obesity and diabetes than those of white European ancestry. The patterns and distributions of diabetes have led some to speculate that the disease is caused by interactions between genetic and obesogenic lifestyle factors. Whilst to many this is a plausible explanation, remarkably little reliable evidence exists to support it. In this review, an overview of published literature relating to genetic and lifestyle risk factors for T2D is provided. The review also describes the concepts and rationale that have motivated the view that gene-lifestyle interactions cause diabetes and overviews the empirical evidence published to date to support this hypothesis. |
| format | Article |
| id | doaj-art-be31f1fbab03499ba85f0776d2bdc424 |
| institution | DOAJ |
| issn | 2090-908X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-be31f1fbab03499ba85f0776d2bdc4242025-08-20T03:23:03ZengWileyScientifica2090-908X2012-01-01201210.6064/2012/482186482186The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An OverviewPaul W. Franks0Genetic & Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, 205 02 Malmö, SwedenType 2 diabetes (T2D) is one of the scourges of modern times, with many millions of people affected by the disease. Diabetes occurs most frequently in those who are overweight or obese. However, not all overweight and obese persons develop diabetes, and there are those who develop the disease who are lean and physically active. Certain ethnicities, especially indigenous populations, are at considerably higher risk of obesity and diabetes than those of white European ancestry. The patterns and distributions of diabetes have led some to speculate that the disease is caused by interactions between genetic and obesogenic lifestyle factors. Whilst to many this is a plausible explanation, remarkably little reliable evidence exists to support it. In this review, an overview of published literature relating to genetic and lifestyle risk factors for T2D is provided. The review also describes the concepts and rationale that have motivated the view that gene-lifestyle interactions cause diabetes and overviews the empirical evidence published to date to support this hypothesis.http://dx.doi.org/10.6064/2012/482186 |
| spellingShingle | Paul W. Franks The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An Overview Scientifica |
| title | The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An Overview |
| title_full | The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An Overview |
| title_fullStr | The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An Overview |
| title_full_unstemmed | The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An Overview |
| title_short | The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An Overview |
| title_sort | complex interplay of genetic and lifestyle risk factors in type 2 diabetes an overview |
| url | http://dx.doi.org/10.6064/2012/482186 |
| work_keys_str_mv | AT paulwfranks thecomplexinterplayofgeneticandlifestyleriskfactorsintype2diabetesanoverview AT paulwfranks complexinterplayofgeneticandlifestyleriskfactorsintype2diabetesanoverview |