Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade

Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade

Abstract Emerging evidence suggests a role for radiation in eliciting anti‐tumour immunity. We aimed to investigate the role of macrophages in modulating the immune response to radiation. Irradiation to murine tumours generated from colorectal (MC38) and pancreatic (KPC) cell lines induced colony‐st...

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Bibliographic Details
Main Authors:	Keaton I Jones, Jiske Tiersma, Arseniy E Yuzhalin, Alex N Gordon‐Weeks, Jon Buzzelli, Jae Hong Im, Ruth J Muschel
Format:	Article
Language:	English
Published:	Springer Nature 2018-11-01
Series:	EMBO Molecular Medicine
Subjects:	immunosuppression immunotherapy macrophage radiation
Online Access:	https://doi.org/10.15252/emmm.201809342
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