Ramelteon used to treat insomnia can reduce the occurrence of osteoporosis
Aim: Melatonin promoted osteoblast differentiation and causes an increase in levels of markers of bone differentiation and proliferation. Ramelteon (RAMEL) activates melatonin receptors and binds to these receptors as non-selective. In this study, we investigated the preventive effects of the melato...
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| Format: | Article |
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Alanya Alaaddin Keykubat University
2021-08-01
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| Series: | Acta Medica Alanya |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1775561 |
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| author | Duygu Köse Zekai Halıcı Muhammed Yayla Muhammed Ali Gürbüz Adem Maman Ahmet Köse |
| author_facet | Duygu Köse Zekai Halıcı Muhammed Yayla Muhammed Ali Gürbüz Adem Maman Ahmet Köse |
| author_sort | Duygu Köse |
| collection | DOAJ |
| description | Aim: Melatonin promoted osteoblast differentiation and causes an increase in levels of markers of bone differentiation and proliferation. Ramelteon (RAMEL) activates melatonin receptors and binds to these receptors as non-selective. In this study, we investigated the preventive effects of the melatonin agonist RAMEL on osteoporosis by radiological, histological, and molecularly.Methods: Groups 1: Control, Group 2: Osteoporosis: Overectomized group (OP), Group 3: OP + ramelteon 2 mg/kg, Group 4: OP + ramelteon 4 mg/kg. 24 animals underwent bilateral ovariectomy. RAMEL was administered orally once a day in the prophylactic treatment mode for 8 weeks, 6 weeks after ovariectomy.Results: Fourteen weeks after ovariectomy, there was a significant reduction in femoral bone mineral density (BMD) (g/cm2) in the OP group compared to the control group. Compared to the OP group, RAMEL treatment significantly increased the BMD level (p<0.05). Bone matrix protein 2 (BMP2) and runt-related transcription factor 2 (RUNX2) mRNA levels were significantly lower in the OP group than in the control group (p<0.05). RUNX2 and BMP2 mRNA levels were significantly higher in the RAMEL treatment groups than in the OP group (p<0.05).Conclusion: To take advantage of the peripheral effects of melatonin, RAMEL, a peripheral melatonin agonist, can be used to prevent osteoporosis. |
| format | Article |
| id | doaj-art-be2f7d1a21924553997b68e287b80dbf |
| institution | Kabale University |
| issn | 2587-0319 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj-art-be2f7d1a21924553997b68e287b80dbf2025-08-20T03:53:22ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192021-08-015216417010.30565/medalanya.939161727Ramelteon used to treat insomnia can reduce the occurrence of osteoporosisDuygu Köse0https://orcid.org/0000-0002-3468-1567Zekai Halıcı1https://orcid.org/0000-0001-6854-6059Muhammed Yayla2https://orcid.org/0000-0002-0659-3084Muhammed Ali Gürbüz3https://orcid.org/0000-0001-8750-2393Adem Maman4https://orcid.org/0000-0002-7742-1028Ahmet Köse5https://orcid.org/0000-0002-7744-1029ATATURK UNIVERSITYATATURK UNIVERSITYKAFKAS UNIVERSITYATATURK UNIVERSITYATATURK UNIVERSITYUNIVERSITY OF HEALTH SCIENCES, ERZURUM REGION HEALTH RESEARCH CENTERAim: Melatonin promoted osteoblast differentiation and causes an increase in levels of markers of bone differentiation and proliferation. Ramelteon (RAMEL) activates melatonin receptors and binds to these receptors as non-selective. In this study, we investigated the preventive effects of the melatonin agonist RAMEL on osteoporosis by radiological, histological, and molecularly.Methods: Groups 1: Control, Group 2: Osteoporosis: Overectomized group (OP), Group 3: OP + ramelteon 2 mg/kg, Group 4: OP + ramelteon 4 mg/kg. 24 animals underwent bilateral ovariectomy. RAMEL was administered orally once a day in the prophylactic treatment mode for 8 weeks, 6 weeks after ovariectomy.Results: Fourteen weeks after ovariectomy, there was a significant reduction in femoral bone mineral density (BMD) (g/cm2) in the OP group compared to the control group. Compared to the OP group, RAMEL treatment significantly increased the BMD level (p<0.05). Bone matrix protein 2 (BMP2) and runt-related transcription factor 2 (RUNX2) mRNA levels were significantly lower in the OP group than in the control group (p<0.05). RUNX2 and BMP2 mRNA levels were significantly higher in the RAMEL treatment groups than in the OP group (p<0.05).Conclusion: To take advantage of the peripheral effects of melatonin, RAMEL, a peripheral melatonin agonist, can be used to prevent osteoporosis.https://dergipark.org.tr/tr/download/article-file/1775561melatonin;bone;rameltone;osteoporosis;ramelteonmelatoninosteoporoz;kemik; |
| spellingShingle | Duygu Köse Zekai Halıcı Muhammed Yayla Muhammed Ali Gürbüz Adem Maman Ahmet Köse Ramelteon used to treat insomnia can reduce the occurrence of osteoporosis Acta Medica Alanya melatonin; bone; rameltone; osteoporosis; ramelteon melatonin osteoporoz; kemik; |
| title | Ramelteon used to treat insomnia can reduce the occurrence of osteoporosis |
| title_full | Ramelteon used to treat insomnia can reduce the occurrence of osteoporosis |
| title_fullStr | Ramelteon used to treat insomnia can reduce the occurrence of osteoporosis |
| title_full_unstemmed | Ramelteon used to treat insomnia can reduce the occurrence of osteoporosis |
| title_short | Ramelteon used to treat insomnia can reduce the occurrence of osteoporosis |
| title_sort | ramelteon used to treat insomnia can reduce the occurrence of osteoporosis |
| topic | melatonin; bone; rameltone; osteoporosis; ramelteon melatonin osteoporoz; kemik; |
| url | https://dergipark.org.tr/tr/download/article-file/1775561 |
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