JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1/PGC-1α/mitophagy axis in hypertensive nephropathy

JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1/PGC-1α/mitophagy axis in hypertensive nephropathy

IntroductionWith the increasing prevalence of hypertension, the incidence of kidney diseases is also increasing, resulting in a serious public burden. Jiangya Tongluo decoction (JYTL), a recognized prescription in traditional Chinese medicine (TCM), is commonly used to calm an overactive liver and r...

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Bibliographic Details
Main Authors: Yun Zhao, Qi Jia, Gaimei Hao, Lin Han, Yushan Gao, Xiaoyu Zhang, Ziming Yan, Boyang Li, Yiping Wu, Boya Zhang, Yubo Li, Jianguo Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
hypertensive nephropathy
tubulointerstitial fibrosis
mitochondrial dysfunction
SIRT1
mitophagy
Chinese medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1491315/full
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