Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes

Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes

During corneal wound healing, transforming growth factor-beta 1 (TGF-β1) causes differentiation of quiescent keratocytes into myofibroblasts. Decorin has been investigated as a promising anti-fibrotic therapeutic for corneal healing due to its interaction with TGF-β1, collagen, and cell surface rece...

Full description

Saved in:
Bibliographic Details
Main Authors: Nathaniel S. Tjahjono, Divya Subramanian, Tarik Z. Shihabeddin, Hudson D. Hicks, Victor D. Varner, W. Matthew Petroll, David W. Schmidtke
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Bioengineering
Subjects:
decorin
aligned collagen fibrils
corneal keratocytes
transforming growth factor-beta
alpha-smooth muscle actin
Online Access:https://www.mdpi.com/2306-5354/12/3/259
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items