The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke
Ischemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality and disability rates. At present, the incidence of IS is increasing annually, with a notable trend towards younger affected individuals. Recent discoveries conc...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999612500052X |
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| author | Liying Chen Xi Wang Shiqi Wang Weili Liu Zhangyong Song Huiling Liao |
| author_facet | Liying Chen Xi Wang Shiqi Wang Weili Liu Zhangyong Song Huiling Liao |
| author_sort | Liying Chen |
| collection | DOAJ |
| description | Ischemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality and disability rates. At present, the incidence of IS is increasing annually, with a notable trend towards younger affected individuals. Recent discoveries concerning the “gut-brain axis” have established a connection between the gut and the brain. Numerous studies have revealed that intestinal microbes play a crucial role in the onset, progression, and outcomes of IS. They are involved in the entire pathophysiological process of IS through mechanisms such as chronic inflammation, neural regulation, and metabolic processes. Although numerous studies have explored the relationship between IS and intestinal microbiota, comprehensive analyses of specific microbiota is relatively scarce. Therefore, this paper provides an overview of the typical changes in gut microbiota following IS and investigates the role of specific microorganisms in this context. Additionally, it presents a comprehensive analysis of post-stroke microbiological therapy and the relationship between IS and diet. The aim is to identify potential microbial targets for therapeutic intervention, as well as to highlight the benefits of microbiological therapies and the significance of dietary management. Overall, this paper seeks to provide key strategies for the treatment and management of IS, advocating for healthy diets and health programs for individuals. Meanwhile, it may offer a new perspective on the future interdisciplinary development of neurology, microbiology and nutrition. |
| format | Article |
| id | doaj-art-be23da028e7a4c649e417c739692fd21 |
| institution | DOAJ |
| issn | 1095-953X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-be23da028e7a4c649e417c739692fd212025-08-20T02:55:46ZengElsevierNeurobiology of Disease1095-953X2025-04-0120710683610.1016/j.nbd.2025.106836The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic strokeLiying Chen0Xi Wang1Shiqi Wang2Weili Liu3Zhangyong Song4Huiling Liao5Geriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaGeriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaGeriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaGeriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaSouthwest Medical University, 646000 Luzhou, China; Corresponding authors.Corresponding authors.; Geriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China; Southwest Medical University, 646000 Luzhou, China; Neurology Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaIschemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality and disability rates. At present, the incidence of IS is increasing annually, with a notable trend towards younger affected individuals. Recent discoveries concerning the “gut-brain axis” have established a connection between the gut and the brain. Numerous studies have revealed that intestinal microbes play a crucial role in the onset, progression, and outcomes of IS. They are involved in the entire pathophysiological process of IS through mechanisms such as chronic inflammation, neural regulation, and metabolic processes. Although numerous studies have explored the relationship between IS and intestinal microbiota, comprehensive analyses of specific microbiota is relatively scarce. Therefore, this paper provides an overview of the typical changes in gut microbiota following IS and investigates the role of specific microorganisms in this context. Additionally, it presents a comprehensive analysis of post-stroke microbiological therapy and the relationship between IS and diet. The aim is to identify potential microbial targets for therapeutic intervention, as well as to highlight the benefits of microbiological therapies and the significance of dietary management. Overall, this paper seeks to provide key strategies for the treatment and management of IS, advocating for healthy diets and health programs for individuals. Meanwhile, it may offer a new perspective on the future interdisciplinary development of neurology, microbiology and nutrition.http://www.sciencedirect.com/science/article/pii/S096999612500052XIschemic strokeIntestinal microenvironmentGut microbiotamicrobiome-gut-brain axisTreatment |
| spellingShingle | Liying Chen Xi Wang Shiqi Wang Weili Liu Zhangyong Song Huiling Liao The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke Neurobiology of Disease Ischemic stroke Intestinal microenvironment Gut microbiota microbiome-gut-brain axis Treatment |
| title | The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke |
| title_full | The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke |
| title_fullStr | The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke |
| title_full_unstemmed | The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke |
| title_short | The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke |
| title_sort | impact of gut microbiota on the occurrence treatment and prognosis of ischemic stroke |
| topic | Ischemic stroke Intestinal microenvironment Gut microbiota microbiome-gut-brain axis Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S096999612500052X |
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