Nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic Japanese adults
Abstract The global rise in obesity and diabetes has been paralleled by a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD). Although previous studies have explored the association between body roundness index (BRI) and MASLD, the specific relationship in non-diabe...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-99540-5 |
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| author | Cheng Huang Zhichao Gao Zhenxia Huang Junfeng Xu |
| author_facet | Cheng Huang Zhichao Gao Zhenxia Huang Junfeng Xu |
| author_sort | Cheng Huang |
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| description | Abstract The global rise in obesity and diabetes has been paralleled by a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD). Although previous studies have explored the association between body roundness index (BRI) and MASLD, the specific relationship in non-diabetic Japanese adults requires further investigation. This study analyzed data from 15,299 participants enrolled in the NAGALA cohort (2004–2015) to explore the association between BRI and MASLD through multivariable logistic regression, stratified analysis, and restricted cubic spline modeling. The prevalence of MASLD was 14.46%, with 13.73% occurring in non-obese individuals (BMI < 30). After adjusting for all confounding factors, BRI demonstrated a significant association with MASLD, yielding an adjusted odds ratio of 1.72 (95% CI 1.48–1.99). The restricted cubic spline model revealed a nonlinear relationship, with an inflection point at 3.06. Stratified analyses revealed stronger associations in individuals with lower BMI (≤ 24 kg/m2). |
| format | Article |
| id | doaj-art-be2135ada6c241d3943dbbd7f1e941fc |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-be2135ada6c241d3943dbbd7f1e941fc2025-08-20T03:52:20ZengNature PortfolioScientific Reports2045-23222025-05-011511910.1038/s41598-025-99540-5Nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic Japanese adultsCheng Huang0Zhichao Gao1Zhenxia Huang2Junfeng Xu3Department of Colorectal Surgery, First People’s Hospital of Xiaoshan DistrictDepartment of Neurosurgery, First People’s Hospital of Xiaoshan DistrictDepartment of Infectious Diseases, First People’s Hospital of Xiaoshan DistrictDepartment of Colorectal Surgery, First People’s Hospital of Xiaoshan DistrictAbstract The global rise in obesity and diabetes has been paralleled by a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD). Although previous studies have explored the association between body roundness index (BRI) and MASLD, the specific relationship in non-diabetic Japanese adults requires further investigation. This study analyzed data from 15,299 participants enrolled in the NAGALA cohort (2004–2015) to explore the association between BRI and MASLD through multivariable logistic regression, stratified analysis, and restricted cubic spline modeling. The prevalence of MASLD was 14.46%, with 13.73% occurring in non-obese individuals (BMI < 30). After adjusting for all confounding factors, BRI demonstrated a significant association with MASLD, yielding an adjusted odds ratio of 1.72 (95% CI 1.48–1.99). The restricted cubic spline model revealed a nonlinear relationship, with an inflection point at 3.06. Stratified analyses revealed stronger associations in individuals with lower BMI (≤ 24 kg/m2).https://doi.org/10.1038/s41598-025-99540-5Body roundness index (BRI)Metabolic dysfunction associated steatotic liver disease (MASLD)ObesityNon-diabetic JapaneseNonlinear |
| spellingShingle | Cheng Huang Zhichao Gao Zhenxia Huang Junfeng Xu Nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic Japanese adults Scientific Reports Body roundness index (BRI) Metabolic dysfunction associated steatotic liver disease (MASLD) Obesity Non-diabetic Japanese Nonlinear |
| title | Nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic Japanese adults |
| title_full | Nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic Japanese adults |
| title_fullStr | Nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic Japanese adults |
| title_full_unstemmed | Nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic Japanese adults |
| title_short | Nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic Japanese adults |
| title_sort | nonlinear association between body roundness index and metabolic dysfunction associated steatotic liver disease in nondiabetic japanese adults |
| topic | Body roundness index (BRI) Metabolic dysfunction associated steatotic liver disease (MASLD) Obesity Non-diabetic Japanese Nonlinear |
| url | https://doi.org/10.1038/s41598-025-99540-5 |
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