Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional study
Purpose Meteorin-like (Metrnl) is a novel adipokine which is highly expressed in adipose tissue and has a beneficial effect on glucose and lipid metabolism. High density lipoprotein cholesterol (HDL-C) is well recognized to be inversely associated with cardiovascular events. However, the relationshi...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2024-10-01
|
| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/18264.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850190764979519488 |
|---|---|
| author | Chenxia Zhou Juli Zeng Xiangyu Gao Da Chen Qiugen Zhu Bo Feng Jun Song |
| author_facet | Chenxia Zhou Juli Zeng Xiangyu Gao Da Chen Qiugen Zhu Bo Feng Jun Song |
| author_sort | Chenxia Zhou |
| collection | DOAJ |
| description | Purpose Meteorin-like (Metrnl) is a novel adipokine which is highly expressed in adipose tissue and has a beneficial effect on glucose and lipid metabolism. High density lipoprotein cholesterol (HDL-C) is well recognized to be inversely associated with cardiovascular events. However, the relationship between serum Metrnl levels and HDL-C in the type 2 diabetes mellitus (T2DM) remains unclear. Therefore, the present study aimed to evaluate the association of serum Metrnl with HDL-C levels in T2DM. Materials and Methods Eighty participants with T2DM were included in this cross-sectional study. They were divided into two groups according to HDL-C levels: Group1 (lower HDL-C group): HDL-C < 1.04 mmol/L; Group2 (higher HDL-C group): HDL-C ≥ 1.04 mmol/L. Serum Metrnl levels were measured by enzyme-linked immunosorbent assay (ELISA). Results As compared with lower HDL-C levels groups, serum Metrnl levels were significantly higher in the group with higher HDL-C. Binary logistic regression analysis showed serum Metrnl levels were positively associated with HDL-C group after adjustment with sex, age, body mass index (BMI), mean arterial pressure (MAP), fasting blood glucose (FPG), triglyceride (TG). Furthermore, serum Metrnl levels were inversely correlated with insulin resistance index (HOMA-IR). HDL-C levels were lowest in the group with the lowest Metrnl levels group and remained positively associated with Metrnl after adjustment for sex, age, BMI, TG, and HOMA-IR by using multivariate logistic regression analysis. Conclusion Serum Metrnl levels were positively associated with HDL-C levels in patients with T2DM.This suggests that increasing serum Metrnl levels maybe a candidate for improving lipid metabolism and preventing cardiovascular events in T2DM. Registry and the Registration No. of the Study/Trial The study was registered in the Chinese clinical trial registry (ChiCTR- 2100047148). |
| format | Article |
| id | doaj-art-be1b6a334e55457ebf171dbfeef5ab19 |
| institution | OA Journals |
| issn | 2167-8359 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-be1b6a334e55457ebf171dbfeef5ab192025-08-20T02:15:11ZengPeerJ Inc.PeerJ2167-83592024-10-0112e1826410.7717/peerj.18264Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional studyChenxia Zhou0Juli Zeng1Xiangyu Gao2Da Chen3Qiugen Zhu4Bo Feng5Jun Song6Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, Shanghai, ChinaDepartment of Endocrinology, Shanghai East Hospital, Ji’An Hospital, Jiangxi, Ji’An, ChinaDepartment of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, Shanghai, ChinaDepartment of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, Shanghai, ChinaDepartment of Endocrinology, Shanghai East Hospital, Ji’An Hospital, Jiangxi, Ji’An, ChinaDepartment of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, Shanghai, ChinaDepartment of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, Shanghai, ChinaPurpose Meteorin-like (Metrnl) is a novel adipokine which is highly expressed in adipose tissue and has a beneficial effect on glucose and lipid metabolism. High density lipoprotein cholesterol (HDL-C) is well recognized to be inversely associated with cardiovascular events. However, the relationship between serum Metrnl levels and HDL-C in the type 2 diabetes mellitus (T2DM) remains unclear. Therefore, the present study aimed to evaluate the association of serum Metrnl with HDL-C levels in T2DM. Materials and Methods Eighty participants with T2DM were included in this cross-sectional study. They were divided into two groups according to HDL-C levels: Group1 (lower HDL-C group): HDL-C < 1.04 mmol/L; Group2 (higher HDL-C group): HDL-C ≥ 1.04 mmol/L. Serum Metrnl levels were measured by enzyme-linked immunosorbent assay (ELISA). Results As compared with lower HDL-C levels groups, serum Metrnl levels were significantly higher in the group with higher HDL-C. Binary logistic regression analysis showed serum Metrnl levels were positively associated with HDL-C group after adjustment with sex, age, body mass index (BMI), mean arterial pressure (MAP), fasting blood glucose (FPG), triglyceride (TG). Furthermore, serum Metrnl levels were inversely correlated with insulin resistance index (HOMA-IR). HDL-C levels were lowest in the group with the lowest Metrnl levels group and remained positively associated with Metrnl after adjustment for sex, age, BMI, TG, and HOMA-IR by using multivariate logistic regression analysis. Conclusion Serum Metrnl levels were positively associated with HDL-C levels in patients with T2DM.This suggests that increasing serum Metrnl levels maybe a candidate for improving lipid metabolism and preventing cardiovascular events in T2DM. Registry and the Registration No. of the Study/Trial The study was registered in the Chinese clinical trial registry (ChiCTR- 2100047148).https://peerj.com/articles/18264.pdfMeteorin-likeDyslipidemiaHigh-density lipoprotein cholesterolT2DM |
| spellingShingle | Chenxia Zhou Juli Zeng Xiangyu Gao Da Chen Qiugen Zhu Bo Feng Jun Song Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional study PeerJ Meteorin-like Dyslipidemia High-density lipoprotein cholesterol T2DM |
| title | Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_full | Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_fullStr | Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_full_unstemmed | Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_short | Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_sort | association of serum metrnl levels and high density lipoprotein cholesterol in patients with type 2 diabetes mellitus a cross sectional study |
| topic | Meteorin-like Dyslipidemia High-density lipoprotein cholesterol T2DM |
| url | https://peerj.com/articles/18264.pdf |
| work_keys_str_mv | AT chenxiazhou associationofserummetrnllevelsandhighdensitylipoproteincholesterolinpatientswithtype2diabetesmellitusacrosssectionalstudy AT julizeng associationofserummetrnllevelsandhighdensitylipoproteincholesterolinpatientswithtype2diabetesmellitusacrosssectionalstudy AT xiangyugao associationofserummetrnllevelsandhighdensitylipoproteincholesterolinpatientswithtype2diabetesmellitusacrosssectionalstudy AT dachen associationofserummetrnllevelsandhighdensitylipoproteincholesterolinpatientswithtype2diabetesmellitusacrosssectionalstudy AT qiugenzhu associationofserummetrnllevelsandhighdensitylipoproteincholesterolinpatientswithtype2diabetesmellitusacrosssectionalstudy AT bofeng associationofserummetrnllevelsandhighdensitylipoproteincholesterolinpatientswithtype2diabetesmellitusacrosssectionalstudy AT junsong associationofserummetrnllevelsandhighdensitylipoproteincholesterolinpatientswithtype2diabetesmellitusacrosssectionalstudy |