Osteomyelitis Caused by <i>Moesziomyces aphidis</i> in an Immunocompetent Adult: A Case Report and Literature Review
Osteomyelitis caused by <i>Moesziomyces aphidis</i> is exceedingly rare and, to our knowledge, has not been previously reported in immunocompetent individuals. This case represents the first documented instance. A 19-year-old woman developed osteomyelitis following an open right leg frac...
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2025-04-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/10/4/107 |
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| author | Yi-Ying Chen Ting-Kuang Yeh Chi-Jung Wu Po-Yu Liu |
| author_facet | Yi-Ying Chen Ting-Kuang Yeh Chi-Jung Wu Po-Yu Liu |
| author_sort | Yi-Ying Chen |
| collection | DOAJ |
| description | Osteomyelitis caused by <i>Moesziomyces aphidis</i> is exceedingly rare and, to our knowledge, has not been previously reported in immunocompetent individuals. This case represents the first documented instance. A 19-year-old woman developed osteomyelitis following an open right leg fracture sustained in a traffic accident. Initial cultures yielded an unidentified yeast, later identified as <i>M. aphidis</i> through internal transcribed spacer sequencing. The patient demonstrated clinical improvement with combination therapy of amphotericin B and following oral voriconazole. This case underscores the emerging pathogenic potential of <i>Moesziomyces</i> spp., particularly in the setting of trauma and open wounds, and highlights the importance of including this genus in the differential diagnosis of osteomyelitis. A literature review indicates that <i>Moesziomyces</i> infections are predominantly observed in immunocompromised patients, especially in Asia. However, our case underscores the need for greater awareness of this emerging pathogen in immunocompetent hosts as well. |
| format | Article |
| id | doaj-art-be197ca51b48413cbba46cdc58e75044 |
| institution | DOAJ |
| issn | 2414-6366 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-be197ca51b48413cbba46cdc58e750442025-08-20T03:13:48ZengMDPI AGTropical Medicine and Infectious Disease2414-63662025-04-0110410710.3390/tropicalmed10040107Osteomyelitis Caused by <i>Moesziomyces aphidis</i> in an Immunocompetent Adult: A Case Report and Literature ReviewYi-Ying Chen0Ting-Kuang Yeh1Chi-Jung Wu2Po-Yu Liu3Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, TaiwanNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan 704, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, TaiwanOsteomyelitis caused by <i>Moesziomyces aphidis</i> is exceedingly rare and, to our knowledge, has not been previously reported in immunocompetent individuals. This case represents the first documented instance. A 19-year-old woman developed osteomyelitis following an open right leg fracture sustained in a traffic accident. Initial cultures yielded an unidentified yeast, later identified as <i>M. aphidis</i> through internal transcribed spacer sequencing. The patient demonstrated clinical improvement with combination therapy of amphotericin B and following oral voriconazole. This case underscores the emerging pathogenic potential of <i>Moesziomyces</i> spp., particularly in the setting of trauma and open wounds, and highlights the importance of including this genus in the differential diagnosis of osteomyelitis. A literature review indicates that <i>Moesziomyces</i> infections are predominantly observed in immunocompromised patients, especially in Asia. However, our case underscores the need for greater awareness of this emerging pathogen in immunocompetent hosts as well.https://www.mdpi.com/2414-6366/10/4/107<i>Moesziomyces</i>ITS sequencingosteomyelitisamphotericin Bvoriconazole |
| spellingShingle | Yi-Ying Chen Ting-Kuang Yeh Chi-Jung Wu Po-Yu Liu Osteomyelitis Caused by <i>Moesziomyces aphidis</i> in an Immunocompetent Adult: A Case Report and Literature Review Tropical Medicine and Infectious Disease <i>Moesziomyces</i> ITS sequencing osteomyelitis amphotericin B voriconazole |
| title | Osteomyelitis Caused by <i>Moesziomyces aphidis</i> in an Immunocompetent Adult: A Case Report and Literature Review |
| title_full | Osteomyelitis Caused by <i>Moesziomyces aphidis</i> in an Immunocompetent Adult: A Case Report and Literature Review |
| title_fullStr | Osteomyelitis Caused by <i>Moesziomyces aphidis</i> in an Immunocompetent Adult: A Case Report and Literature Review |
| title_full_unstemmed | Osteomyelitis Caused by <i>Moesziomyces aphidis</i> in an Immunocompetent Adult: A Case Report and Literature Review |
| title_short | Osteomyelitis Caused by <i>Moesziomyces aphidis</i> in an Immunocompetent Adult: A Case Report and Literature Review |
| title_sort | osteomyelitis caused by i moesziomyces aphidis i in an immunocompetent adult a case report and literature review |
| topic | <i>Moesziomyces</i> ITS sequencing osteomyelitis amphotericin B voriconazole |
| url | https://www.mdpi.com/2414-6366/10/4/107 |
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