Stephanine interacts with TNF-α to block NF-κB signaling and protects against rheumatoid arthritis

Stephanine interacts with TNF-α to block NF-κB signaling and protects against rheumatoid arthritis

Tumor necrosis factor-α (TNF-α) is a key player in the pathogenesis of rheumatoid arthritis (RA) and considered a promising target for therapeutic drug development. Activation of the nuclear factor-kappa B (NF-κB) pathway upon TNF-α binding to its receptor is crucial for progression of RA. Stephanin...

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Bibliographic Details
Main Authors: Titi Liu, Meiyan Duan, Jin Li, Wei Dong, Yingqi Yin, Honglei Hui, Jing Xu, Zhe Jiang, Chunxia Gan, Zemin Xiang, Jun Sheng, Xuanjun Wang, Huanhuan Xu
Format: Article
Language:English
Published: Tsinghua University Press 2025-07-01
Series:Food Science and Human Wellness
Subjects:
stephanine
tnf-α-tumor necrosis factor receptor interaction
nf-κb signaling
rheumatoid arthritis
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2025.9250551
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