Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers
The aim of review. To demonstrate value of disorders of cholinergic innervation in pathogenesis of irritable bowel syndrome (IBS).Original positions. The important place in regulation of gastro-intestinal tract functions belongs not only to M-, but also to N-receptors localized in enteral plexus gan...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2011-02-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1365 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860228313055232 |
|---|---|
| author | Yu. O. Shulpekova |
| author_facet | Yu. O. Shulpekova |
| author_sort | Yu. O. Shulpekova |
| collection | DOAJ |
| description | The aim of review. To demonstrate value of disorders of cholinergic innervation in pathogenesis of irritable bowel syndrome (IBS).Original positions. The important place in regulation of gastro-intestinal tract functions belongs not only to M-, but also to N-receptors localized in enteral plexus ganglions and on presynaptic endings of cholinergic motor neurones. Acetylcholine is the universal mediator which is intimately interacts with other mediators regulating intestinal functions. The role of disorders of cholinergic innervation in pathogenesis of IBS is actively investigated by now. Experimental data allow to assume, that «subclinical inflammation» within intestinal wall at IBS, disturbances of peristaltic activity and hyperalgesia, are related to altered response of immune and smooth-muscle cells to acetylcholine stimulation.Conclusion. Acetylcholine represents the major mediator regulating motor and secretory function of intestine. Change of acetylcholine metabolism of has immediate value in pathogenesis of IBS. The agents, influencing cholinergic receptors, are one of basic resources of modern pharmaceutical therapy of irritable bowel syndrome. |
| format | Article |
| id | doaj-art-be062e61c2fd4d2b821a8766e2511b67 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2011-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-be062e61c2fd4d2b821a8766e2511b672025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732011-02-012112631917Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockersYu. O. Shulpekova0ГОУ ВПО «1-й Московский государственный медицинский университет им. И.М. Сеченова Росздрава»The aim of review. To demonstrate value of disorders of cholinergic innervation in pathogenesis of irritable bowel syndrome (IBS).Original positions. The important place in regulation of gastro-intestinal tract functions belongs not only to M-, but also to N-receptors localized in enteral plexus ganglions and on presynaptic endings of cholinergic motor neurones. Acetylcholine is the universal mediator which is intimately interacts with other mediators regulating intestinal functions. The role of disorders of cholinergic innervation in pathogenesis of IBS is actively investigated by now. Experimental data allow to assume, that «subclinical inflammation» within intestinal wall at IBS, disturbances of peristaltic activity and hyperalgesia, are related to altered response of immune and smooth-muscle cells to acetylcholine stimulation.Conclusion. Acetylcholine represents the major mediator regulating motor and secretory function of intestine. Change of acetylcholine metabolism of has immediate value in pathogenesis of IBS. The agents, influencing cholinergic receptors, are one of basic resources of modern pharmaceutical therapy of irritable bowel syndrome.https://www.gastro-j.ru/jour/article/view/1365irritable bowel syndromeacetylcholinecholinoblockershyoscine butylbromide |
| spellingShingle | Yu. O. Shulpekova Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers Российский журнал гастроэнтерологии, гепатологии, колопроктологии irritable bowel syndrome acetylcholine cholinoblockers hyoscine butylbromide |
| title | Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers |
| title_full | Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers |
| title_fullStr | Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers |
| title_full_unstemmed | Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers |
| title_short | Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers |
| title_sort | acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers |
| topic | irritable bowel syndrome acetylcholine cholinoblockers hyoscine butylbromide |
| url | https://www.gastro-j.ru/jour/article/view/1365 |
| work_keys_str_mv | AT yuoshulpekova acetylcholineinirritablebowelsyndromepathogenesisandtheroleofcholineblockers |