Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised Patient
In a patient on immunosuppressant treatment, SARS-CoV-2 RNA was documented in different extra-respiratory samples over several months in the absence of positive determinations in upper respiratory samples. Whole-genome sequencing of these samples showed the acquisition of different single-nucleotide...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/2/147 |
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| author | Francisco Tejerina Daniel Peñas-Utrilla Marta Herranz Pilar Catalán Mercedes Marín Lara Mesones José Manuel García-Domínguez Beatriz Merino Leire Pérez Chiara Fanciulli Patricia Muñoz Carmen Rodríguez-Gonzalez Cristina Diez Teresa Aldámiz Andrea Molero-Salinas Laura Pérez-Lago Darío García de Viedma |
| author_facet | Francisco Tejerina Daniel Peñas-Utrilla Marta Herranz Pilar Catalán Mercedes Marín Lara Mesones José Manuel García-Domínguez Beatriz Merino Leire Pérez Chiara Fanciulli Patricia Muñoz Carmen Rodríguez-Gonzalez Cristina Diez Teresa Aldámiz Andrea Molero-Salinas Laura Pérez-Lago Darío García de Viedma |
| author_sort | Francisco Tejerina |
| collection | DOAJ |
| description | In a patient on immunosuppressant treatment, SARS-CoV-2 RNA was documented in different extra-respiratory samples over several months in the absence of positive determinations in upper respiratory samples. Whole-genome sequencing of these samples showed the acquisition of different single-nucleotide polymorphisms over time, suggesting viral evolution and thus viral viability. |
| format | Article |
| id | doaj-art-be046bc9ad2f4e2ab077edfccc3462e7 |
| institution | DOAJ |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-be046bc9ad2f4e2ab077edfccc3462e72025-08-20T03:12:07ZengMDPI AGViruses1999-49152025-01-0117214710.3390/v17020147Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised PatientFrancisco Tejerina0Daniel Peñas-Utrilla1Marta Herranz2Pilar Catalán3Mercedes Marín4Lara Mesones5José Manuel García-Domínguez6Beatriz Merino7Leire Pérez8Chiara Fanciulli9Patricia Muñoz10Carmen Rodríguez-Gonzalez11Cristina Diez12Teresa Aldámiz13Andrea Molero-Salinas14Laura Pérez-Lago15Darío García de Viedma16Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainDepartment of Neurology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainGastroenterology Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainPharmacy Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainInstituto de Investigación Sanitaria Gregorio Marañón, 28009 Madrid, SpainClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainIn a patient on immunosuppressant treatment, SARS-CoV-2 RNA was documented in different extra-respiratory samples over several months in the absence of positive determinations in upper respiratory samples. Whole-genome sequencing of these samples showed the acquisition of different single-nucleotide polymorphisms over time, suggesting viral evolution and thus viral viability.https://www.mdpi.com/1999-4915/17/2/147persistent COVID-19immunocompromisedsystemic infection |
| spellingShingle | Francisco Tejerina Daniel Peñas-Utrilla Marta Herranz Pilar Catalán Mercedes Marín Lara Mesones José Manuel García-Domínguez Beatriz Merino Leire Pérez Chiara Fanciulli Patricia Muñoz Carmen Rodríguez-Gonzalez Cristina Diez Teresa Aldámiz Andrea Molero-Salinas Laura Pérez-Lago Darío García de Viedma Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised Patient Viruses persistent COVID-19 immunocompromised systemic infection |
| title | Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised Patient |
| title_full | Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised Patient |
| title_fullStr | Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised Patient |
| title_full_unstemmed | Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised Patient |
| title_short | Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised Patient |
| title_sort | chronic systemic sars cov 2 infection without respiratory involvement in an immunocompromised patient |
| topic | persistent COVID-19 immunocompromised systemic infection |
| url | https://www.mdpi.com/1999-4915/17/2/147 |
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