Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies
Cardiovascular diseases (CVD) are the primary cause of death and disability around the world. Over the past decades, several conventional model systems based on two-dimensional (3D) monolayer cultures or experimental animals have been adopted to dissect and understand heart diseases in order to deve...
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| Format: | Article |
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MDPI AG
2025-05-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/12/5/518 |
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| author | Abdullah Jabri Bader Taftafa Abdulaziz Mhannayeh Mohamed Alsharif Tasnim Abbad Sana Ahmed Eman A. Alshehri Abdulrahman Elsalti Jibran Khan Tanveer Ahmad Mir Ahmed Yaqinuddin |
| author_facet | Abdullah Jabri Bader Taftafa Abdulaziz Mhannayeh Mohamed Alsharif Tasnim Abbad Sana Ahmed Eman A. Alshehri Abdulrahman Elsalti Jibran Khan Tanveer Ahmad Mir Ahmed Yaqinuddin |
| author_sort | Abdullah Jabri |
| collection | DOAJ |
| description | Cardiovascular diseases (CVD) are the primary cause of death and disability around the world. Over the past decades, several conventional model systems based on two-dimensional (3D) monolayer cultures or experimental animals have been adopted to dissect and understand heart diseases in order to develop treatment modalities. However, traditional models exhibit several limitations in recapitulating human-specific key physiological and pathological characteristics, which highlights the necessity of developing physiologically relevant models. In recent years, tissue engineering approaches have been extensively employed to generate revolutionary three-dimensional (3D) cardiac models. In particular, the combined use of various bioengineering strategies and cellular reprogramming approaches has facilitated the development of various models. This review presents an overview of different approaches (bioprinting, scaffolding, and electrospinning) for creating bioengineered cardiac tissue models. Next, a broad survey of recent research related to the modeling of various cardiac diseases is presented. Finally, current challenges and future directions are proposed to foster further developments in the field of cardiac tissue engineering. |
| format | Article |
| id | doaj-art-be04101b2d1a49d6b3864469fa05e272 |
| institution | OA Journals |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-be04101b2d1a49d6b3864469fa05e2722025-08-20T02:33:30ZengMDPI AGBioengineering2306-53542025-05-0112551810.3390/bioengineering12050518Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative TherapiesAbdullah Jabri0Bader Taftafa1Abdulaziz Mhannayeh2Mohamed Alsharif3Tasnim Abbad4Sana Ahmed5Eman A. Alshehri6Abdulrahman Elsalti7Jibran Khan8Tanveer Ahmad Mir9Ahmed Yaqinuddin10College of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaTissue/Organ Bioengineering & BioMEMS Laboratory, Organ Transplant Centre of Excellence (TR&I-Dpt), King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi ArabiaTissue/Organ Bioengineering & BioMEMS Laboratory, Organ Transplant Centre of Excellence (TR&I-Dpt), King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi ArabiaInternational School of Medicine, Istanbul Medipol University, Istanbul 34810, TurkeyCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaCardiovascular diseases (CVD) are the primary cause of death and disability around the world. Over the past decades, several conventional model systems based on two-dimensional (3D) monolayer cultures or experimental animals have been adopted to dissect and understand heart diseases in order to develop treatment modalities. However, traditional models exhibit several limitations in recapitulating human-specific key physiological and pathological characteristics, which highlights the necessity of developing physiologically relevant models. In recent years, tissue engineering approaches have been extensively employed to generate revolutionary three-dimensional (3D) cardiac models. In particular, the combined use of various bioengineering strategies and cellular reprogramming approaches has facilitated the development of various models. This review presents an overview of different approaches (bioprinting, scaffolding, and electrospinning) for creating bioengineered cardiac tissue models. Next, a broad survey of recent research related to the modeling of various cardiac diseases is presented. Finally, current challenges and future directions are proposed to foster further developments in the field of cardiac tissue engineering.https://www.mdpi.com/2306-5354/12/5/518bioengineeringcardiovascular systemin vitro modelsdisease modelingregenerative medicine |
| spellingShingle | Abdullah Jabri Bader Taftafa Abdulaziz Mhannayeh Mohamed Alsharif Tasnim Abbad Sana Ahmed Eman A. Alshehri Abdulrahman Elsalti Jibran Khan Tanveer Ahmad Mir Ahmed Yaqinuddin Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies Bioengineering bioengineering cardiovascular system in vitro models disease modeling regenerative medicine |
| title | Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies |
| title_full | Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies |
| title_fullStr | Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies |
| title_full_unstemmed | Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies |
| title_short | Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies |
| title_sort | cardiac tissue engineering for translational cardiology from in vitro models to regenerative therapies |
| topic | bioengineering cardiovascular system in vitro models disease modeling regenerative medicine |
| url | https://www.mdpi.com/2306-5354/12/5/518 |
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