Targeting duodenum to reverse MASLD
Yu JW et al. (World J Gastroenterol. 2025;31:105188. DOI: 10.3748/wjg.v31.i16.105188) used male Sprague-Dawley rats fed a high-fat diet for 8 weeks to recapitulate metabolic dysfunction-associated steatotic liver disease (MASLD) experimentally. MASLD rats were randomized to receive either the duoden...
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Open Exploration Publishing Inc.
2025-06-01
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| Series: | Exploration of Digestive Diseases |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100577/100577.pdf |
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| author | Amedeo Lonardo Ming-Hua Zheng |
| author_facet | Amedeo Lonardo Ming-Hua Zheng |
| author_sort | Amedeo Lonardo |
| collection | DOAJ |
| description | Yu JW et al. (World J Gastroenterol. 2025;31:105188. DOI: 10.3748/wjg.v31.i16.105188) used male Sprague-Dawley rats fed a high-fat diet for 8 weeks to recapitulate metabolic dysfunction-associated steatotic liver disease (MASLD) experimentally. MASLD rats were randomized to receive either the duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) during laparotomy or sham DMA. Data have shown that DMA was associated with duodenal thickening compared to the control group, crypts were narrower and shallower crypts and villi slimmer than sham DMA group. Moreover, the DMA group exhibited improved liver histology compared to the sham group though accompanied by inconsistent variations in blood lipid values and statistically non-significant variations in surrogate indices of MASLD. Thirdly, DMA rats had lower serum concentrations of gut hormones with crucial metabolic functions, lower lipopolysaccharide serum level, increased duodenal expression and immunofluorescence staining intensity of gut hormones expression, and higher expression of zonula occludens-1 and claudin than sham-rats. The study by Yu, et al. has innovative findings and is properly designed to illustrate the pathomechanisms underlying improved MASLD histology after DMA with IRE. However, this paper also has some methodological limitations that prompt additional studies in animal models and, ideally, in humans to be conducted as soon as safety and feasibility are demonstrated. |
| format | Article |
| id | doaj-art-be02b80d007c4e6e9c3d5b5186ff9f06 |
| institution | Kabale University |
| issn | 2833-6321 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Open Exploration Publishing Inc. |
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| series | Exploration of Digestive Diseases |
| spelling | doaj-art-be02b80d007c4e6e9c3d5b5186ff9f062025-08-20T03:30:52ZengOpen Exploration Publishing Inc.Exploration of Digestive Diseases2833-63212025-06-01410057710.37349/edd.2025.100577Targeting duodenum to reverse MASLDAmedeo Lonardo0https://orcid.org/0000-0001-9886-0698Ming-Hua Zheng1https://orcid.org/0000-0003-4984-2631Department of Internal Medicine, Azienda Ospedaliero-Universitaria di Modena (–2023), Modena, 41100, ItalyMAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou 325000, Zhejiang, ChinaYu JW et al. (World J Gastroenterol. 2025;31:105188. DOI: 10.3748/wjg.v31.i16.105188) used male Sprague-Dawley rats fed a high-fat diet for 8 weeks to recapitulate metabolic dysfunction-associated steatotic liver disease (MASLD) experimentally. MASLD rats were randomized to receive either the duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) during laparotomy or sham DMA. Data have shown that DMA was associated with duodenal thickening compared to the control group, crypts were narrower and shallower crypts and villi slimmer than sham DMA group. Moreover, the DMA group exhibited improved liver histology compared to the sham group though accompanied by inconsistent variations in blood lipid values and statistically non-significant variations in surrogate indices of MASLD. Thirdly, DMA rats had lower serum concentrations of gut hormones with crucial metabolic functions, lower lipopolysaccharide serum level, increased duodenal expression and immunofluorescence staining intensity of gut hormones expression, and higher expression of zonula occludens-1 and claudin than sham-rats. The study by Yu, et al. has innovative findings and is properly designed to illustrate the pathomechanisms underlying improved MASLD histology after DMA with IRE. However, this paper also has some methodological limitations that prompt additional studies in animal models and, ideally, in humans to be conducted as soon as safety and feasibility are demonstrated.https://www.explorationpub.com/uploads/Article/A100577/100577.pdfduodenal mucosa ablationirreversible electroporationmetabolic dysfunction-associated steatotic liver diseasetype 2 diabetes |
| spellingShingle | Amedeo Lonardo Ming-Hua Zheng Targeting duodenum to reverse MASLD Exploration of Digestive Diseases duodenal mucosa ablation irreversible electroporation metabolic dysfunction-associated steatotic liver disease type 2 diabetes |
| title | Targeting duodenum to reverse MASLD |
| title_full | Targeting duodenum to reverse MASLD |
| title_fullStr | Targeting duodenum to reverse MASLD |
| title_full_unstemmed | Targeting duodenum to reverse MASLD |
| title_short | Targeting duodenum to reverse MASLD |
| title_sort | targeting duodenum to reverse masld |
| topic | duodenal mucosa ablation irreversible electroporation metabolic dysfunction-associated steatotic liver disease type 2 diabetes |
| url | https://www.explorationpub.com/uploads/Article/A100577/100577.pdf |
| work_keys_str_mv | AT amedeolonardo targetingduodenumtoreversemasld AT minghuazheng targetingduodenumtoreversemasld |