Drosophila melanogaster as an alternative animal model in fat metabolism studies
Drosophila melanogaster is one of the most abundantly utilized model organisms today, in various contexts of biomedical research. It serves as one of the best alternative model organisms as it comprises most genes related to metabolism which are conserved in the human genome. The simplicity in genet...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-07-01
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| Series: | BLDE University Journal of Health Sciences |
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| Online Access: | https://journals.lww.com/10.4103/bjhs.bjhs_214_23 |
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| author | Dilan de Silva Mangala Gunatilake |
| author_facet | Dilan de Silva Mangala Gunatilake |
| author_sort | Dilan de Silva |
| collection | DOAJ |
| description | Drosophila melanogaster is one of the most abundantly utilized model organisms today, in various contexts of biomedical research. It serves as one of the best alternative model organisms as it comprises most genes related to metabolism which are conserved in the human genome. The simplicity in genetics as well as their rapid life cycle makes it a righteous model organism that can be efficiently utilized in research. With the latest advances, numerous studies have disclosed the significance of using Drosophila as a model in studying fat metabolism and related diseases as well as potential therapeutic targets. It is discovered that Drosophila accommodates a range of cell types and organs which entail lipid metabolism and related energy homeostasis similar to those of mammals. Fat storage in Drosophila occurs in the form of lipid droplets carrying cholesterol and triacylglycerol which are accumulated primarily in the fat body – the analogous Drosophila organ to mammalian adipose tissue. Moreover, the Drosophila fat body has showcased its role in storage and metabolic regulation, akin to the function of the liver in mammals. Following a comprehensive overlook on Drosophila as a model organism in the study of fat metabolism, this narrative review covers lipid anabolic, enzymatic, and regulatory processes in Drosophila as well as the use of Drosophila in the study of fat metabolism associated diseases. |
| format | Article |
| id | doaj-art-bdfb939b53414c06b36703ac037fde81 |
| institution | Kabale University |
| issn | 2468-838X 2456-1975 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | BLDE University Journal of Health Sciences |
| spelling | doaj-art-bdfb939b53414c06b36703ac037fde812025-02-10T14:41:59ZengWolters Kluwer Medknow PublicationsBLDE University Journal of Health Sciences2468-838X2456-19752024-07-01929710310.4103/bjhs.bjhs_214_23Drosophila melanogaster as an alternative animal model in fat metabolism studiesDilan de SilvaMangala GunatilakeDrosophila melanogaster is one of the most abundantly utilized model organisms today, in various contexts of biomedical research. It serves as one of the best alternative model organisms as it comprises most genes related to metabolism which are conserved in the human genome. The simplicity in genetics as well as their rapid life cycle makes it a righteous model organism that can be efficiently utilized in research. With the latest advances, numerous studies have disclosed the significance of using Drosophila as a model in studying fat metabolism and related diseases as well as potential therapeutic targets. It is discovered that Drosophila accommodates a range of cell types and organs which entail lipid metabolism and related energy homeostasis similar to those of mammals. Fat storage in Drosophila occurs in the form of lipid droplets carrying cholesterol and triacylglycerol which are accumulated primarily in the fat body – the analogous Drosophila organ to mammalian adipose tissue. Moreover, the Drosophila fat body has showcased its role in storage and metabolic regulation, akin to the function of the liver in mammals. Following a comprehensive overlook on Drosophila as a model organism in the study of fat metabolism, this narrative review covers lipid anabolic, enzymatic, and regulatory processes in Drosophila as well as the use of Drosophila in the study of fat metabolism associated diseases.https://journals.lww.com/10.4103/bjhs.bjhs_214_23alternative animal modeldrosophilafat metabolismlipogenesislipolysistriacylglycerol |
| spellingShingle | Dilan de Silva Mangala Gunatilake Drosophila melanogaster as an alternative animal model in fat metabolism studies BLDE University Journal of Health Sciences alternative animal model drosophila fat metabolism lipogenesis lipolysis triacylglycerol |
| title | Drosophila melanogaster as an alternative animal model in fat metabolism studies |
| title_full | Drosophila melanogaster as an alternative animal model in fat metabolism studies |
| title_fullStr | Drosophila melanogaster as an alternative animal model in fat metabolism studies |
| title_full_unstemmed | Drosophila melanogaster as an alternative animal model in fat metabolism studies |
| title_short | Drosophila melanogaster as an alternative animal model in fat metabolism studies |
| title_sort | drosophila melanogaster as an alternative animal model in fat metabolism studies |
| topic | alternative animal model drosophila fat metabolism lipogenesis lipolysis triacylglycerol |
| url | https://journals.lww.com/10.4103/bjhs.bjhs_214_23 |
| work_keys_str_mv | AT dilandesilva drosophilamelanogasterasanalternativeanimalmodelinfatmetabolismstudies AT mangalagunatilake drosophilamelanogasterasanalternativeanimalmodelinfatmetabolismstudies |