Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications
Summary: Inflammation plays a pivotal dual role in disease pathogenesis, acting as both a protective response and a critical factor to chronic inflammatory pathologies. Traditional anti-inflammatory therapies remain constrained by adverse effects and suboptimal bioavailability, necessitating innovat...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396425002816 |
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| author | Hailin Zhang Haoxiang Chen Xinman Hu Wali Muhammad Chenyu Liu Wenxing Liu |
| author_facet | Hailin Zhang Haoxiang Chen Xinman Hu Wali Muhammad Chenyu Liu Wenxing Liu |
| author_sort | Hailin Zhang |
| collection | DOAJ |
| description | Summary: Inflammation plays a pivotal dual role in disease pathogenesis, acting as both a protective response and a critical factor to chronic inflammatory pathologies. Traditional anti-inflammatory therapies remain constrained by adverse effects and suboptimal bioavailability, necessitating innovative therapeutic paradigms. Polymeric nanoparticles (PNPs) have emerged as a promising alternative for inflammation modulation, offering significant drug-loading capacity, precise targeting, biodegradability, and stimuli-responsive properties. This review summarises PNPs as a versatile nanomedicine platform for inflammation modulation. The physiological and pathological mechanisms underlying inflammation are elucidated, followed by a comprehensive summary of the engineering strategies, mechanistic actions, and therapeutic potential of PNPs for inflammation modulation. The clinical translation challenges, including toxicity and off-target effects, are discussed. The potential future directions for multifunctional PNPs in theranostics and AI-driven personalised inflammation modulation are finally proposed. This work seeks to bridge polymeric nanomaterials innovation and precision medicine to drive next-generation anti-inflammatory therapies. |
| format | Article |
| id | doaj-art-bdfa633bc5cc437f8c2cf19715d97b7f |
| institution | DOAJ |
| issn | 2352-3964 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj-art-bdfa633bc5cc437f8c2cf19715d97b7f2025-08-20T03:04:51ZengElsevierEBioMedicine2352-39642025-08-0111810583710.1016/j.ebiom.2025.105837Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applicationsHailin Zhang0Haoxiang Chen1Xinman Hu2Wali Muhammad3Chenyu Liu4Wenxing Liu5MOE Key Laboratory of Macromolecular Synthesis and Functionalisation, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China; Zhejiang Engineering Research Center for Interface Technology of Medical Polymers and Devices, Shaoxing Key Laboratory of Healthcare Materials and Application Technology, and Center for Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312099, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalisation, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China; Zhejiang Engineering Research Center for Interface Technology of Medical Polymers and Devices, Shaoxing Key Laboratory of Healthcare Materials and Application Technology, and Center for Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312099, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalisation, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalisation, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, ChinaZhejiang Engineering Research Center for Interface Technology of Medical Polymers and Devices, Shaoxing Key Laboratory of Healthcare Materials and Application Technology, and Center for Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312099, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalisation, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China; Zhejiang Engineering Research Center for Interface Technology of Medical Polymers and Devices, Shaoxing Key Laboratory of Healthcare Materials and Application Technology, and Center for Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312099, China; Corresponding author. MOE Key Laboratory of Macromolecular Synthesis and Functionalisation, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China.Summary: Inflammation plays a pivotal dual role in disease pathogenesis, acting as both a protective response and a critical factor to chronic inflammatory pathologies. Traditional anti-inflammatory therapies remain constrained by adverse effects and suboptimal bioavailability, necessitating innovative therapeutic paradigms. Polymeric nanoparticles (PNPs) have emerged as a promising alternative for inflammation modulation, offering significant drug-loading capacity, precise targeting, biodegradability, and stimuli-responsive properties. This review summarises PNPs as a versatile nanomedicine platform for inflammation modulation. The physiological and pathological mechanisms underlying inflammation are elucidated, followed by a comprehensive summary of the engineering strategies, mechanistic actions, and therapeutic potential of PNPs for inflammation modulation. The clinical translation challenges, including toxicity and off-target effects, are discussed. The potential future directions for multifunctional PNPs in theranostics and AI-driven personalised inflammation modulation are finally proposed. This work seeks to bridge polymeric nanomaterials innovation and precision medicine to drive next-generation anti-inflammatory therapies.http://www.sciencedirect.com/science/article/pii/S2352396425002816Inflammation modulationPolymeric nanoparticlesNanomedicineTargeted drug deliveryStimuli-responsive systemsImmune regulation |
| spellingShingle | Hailin Zhang Haoxiang Chen Xinman Hu Wali Muhammad Chenyu Liu Wenxing Liu Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications EBioMedicine Inflammation modulation Polymeric nanoparticles Nanomedicine Targeted drug delivery Stimuli-responsive systems Immune regulation |
| title | Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications |
| title_full | Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications |
| title_fullStr | Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications |
| title_full_unstemmed | Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications |
| title_short | Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications |
| title_sort | inflammation modulating polymeric nanoparticles design strategies mechanisms and therapeutic applications |
| topic | Inflammation modulation Polymeric nanoparticles Nanomedicine Targeted drug delivery Stimuli-responsive systems Immune regulation |
| url | http://www.sciencedirect.com/science/article/pii/S2352396425002816 |
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