Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications
Summary: Inflammation plays a pivotal dual role in disease pathogenesis, acting as both a protective response and a critical factor to chronic inflammatory pathologies. Traditional anti-inflammatory therapies remain constrained by adverse effects and suboptimal bioavailability, necessitating innovat...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396425002816 |
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| Summary: | Summary: Inflammation plays a pivotal dual role in disease pathogenesis, acting as both a protective response and a critical factor to chronic inflammatory pathologies. Traditional anti-inflammatory therapies remain constrained by adverse effects and suboptimal bioavailability, necessitating innovative therapeutic paradigms. Polymeric nanoparticles (PNPs) have emerged as a promising alternative for inflammation modulation, offering significant drug-loading capacity, precise targeting, biodegradability, and stimuli-responsive properties. This review summarises PNPs as a versatile nanomedicine platform for inflammation modulation. The physiological and pathological mechanisms underlying inflammation are elucidated, followed by a comprehensive summary of the engineering strategies, mechanistic actions, and therapeutic potential of PNPs for inflammation modulation. The clinical translation challenges, including toxicity and off-target effects, are discussed. The potential future directions for multifunctional PNPs in theranostics and AI-driven personalised inflammation modulation are finally proposed. This work seeks to bridge polymeric nanomaterials innovation and precision medicine to drive next-generation anti-inflammatory therapies. |
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| ISSN: | 2352-3964 |