Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020
Objective: The conicity index (C-index) is recognized for its association with various diseases. However, the relationship between C-index and gallstone disease (GSD) has not been explored. This study aims to investigate the potential relationship between C-index and GSD prevalence. Methods: Using d...
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Elsevier
2025-06-01
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| Series: | Preventive Medicine Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335525001123 |
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| author | Jie Wang Songsheng Zhou Na He Yi Cao Haibiao Wang |
| author_facet | Jie Wang Songsheng Zhou Na He Yi Cao Haibiao Wang |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Objective: The conicity index (C-index) is recognized for its association with various diseases. However, the relationship between C-index and gallstone disease (GSD) has not been explored. This study aims to investigate the potential relationship between C-index and GSD prevalence. Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2017 to 2020, we analyzed the association between C-index and GSD through survey-weighted multivariate logistic regression and restricted cubic spline regression. Receiver operating characteristic (ROC) curve analysis was utilized to compare the predictive performance of C-index, body mass index (BMI), and waist-to-hip ratio (WHR). Results: The study encompassed 3626 participants and revealed a significant positive relationship between C-index and GSD. In the fully adjusted model, each standard deviation increase in C-index was associated with 30 % rise in the odds of GSD prevalence (OR = 1.30; 95 % CI, 1.06 to 1.59; p = 0.036). The restricted cubic spline analysis found no significant nonlinear relationships between C-index and GSD (p-nonlinear = 0.213). C-index demonstrated superior predictive power for GSD when compared to WHR (p < 0.001), and was comparable to BMI (p = 0.483). Conclusions: This research establishes a strong positive association between C-index and GSD prevalence, suggesting that C-index could serve as a valuable clinical marker for the early detection of gallstones. |
| format | Article |
| id | doaj-art-bdf4e19f04de453eb7ce3b6cb2c55cbc |
| institution | DOAJ |
| issn | 2211-3355 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj-art-bdf4e19f04de453eb7ce3b6cb2c55cbc2025-08-20T03:13:03ZengElsevierPreventive Medicine Reports2211-33552025-06-015410307310.1016/j.pmedr.2025.103073Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020Jie Wang0Songsheng Zhou1Na He2Yi Cao3Haibiao Wang4Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315048, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315048, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315048, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315048, ChinaCorresponding author at: Ningbo Medical Center Lihuili Hospital, 57 Xingning Road, Yinzhou District, Ningbo, Zhejiang, China.; Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315048, ChinaObjective: The conicity index (C-index) is recognized for its association with various diseases. However, the relationship between C-index and gallstone disease (GSD) has not been explored. This study aims to investigate the potential relationship between C-index and GSD prevalence. Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2017 to 2020, we analyzed the association between C-index and GSD through survey-weighted multivariate logistic regression and restricted cubic spline regression. Receiver operating characteristic (ROC) curve analysis was utilized to compare the predictive performance of C-index, body mass index (BMI), and waist-to-hip ratio (WHR). Results: The study encompassed 3626 participants and revealed a significant positive relationship between C-index and GSD. In the fully adjusted model, each standard deviation increase in C-index was associated with 30 % rise in the odds of GSD prevalence (OR = 1.30; 95 % CI, 1.06 to 1.59; p = 0.036). The restricted cubic spline analysis found no significant nonlinear relationships between C-index and GSD (p-nonlinear = 0.213). C-index demonstrated superior predictive power for GSD when compared to WHR (p < 0.001), and was comparable to BMI (p = 0.483). Conclusions: This research establishes a strong positive association between C-index and GSD prevalence, suggesting that C-index could serve as a valuable clinical marker for the early detection of gallstones.http://www.sciencedirect.com/science/article/pii/S2211335525001123Conicity indexGallstone diseaseObesityNHANESCross-sectional study |
| spellingShingle | Jie Wang Songsheng Zhou Na He Yi Cao Haibiao Wang Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020 Preventive Medicine Reports Conicity index Gallstone disease Obesity NHANES Cross-sectional study |
| title | Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020 |
| title_full | Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020 |
| title_fullStr | Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020 |
| title_full_unstemmed | Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020 |
| title_short | Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020 |
| title_sort | association between conicity index and gallstone disease a cross sectional study from nhanes 2017 2020 |
| topic | Conicity index Gallstone disease Obesity NHANES Cross-sectional study |
| url | http://www.sciencedirect.com/science/article/pii/S2211335525001123 |
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