Glomerulonephritis and Interstitial Nephritis Originating from Vasculitis of the Interlobular Arteries of the Kidney in a Patient with Eosinophilic Granulomatosis with Polyangiitis
Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of antineutrophil cytoplasmic antibody-associated vasculitis. Patients often present with peripheral neuropathy and purpura, suggesting impairment of small vessels, especially capillaries. However, medium-sized vessels and small vessels...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2022/9606981 |
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| author | Takashi Nawata Masaki Shibuya Yukio Takeshita Makoto Kubo Noriko Uesugi Masafumi Yano |
| author_facet | Takashi Nawata Masaki Shibuya Yukio Takeshita Makoto Kubo Noriko Uesugi Masafumi Yano |
| author_sort | Takashi Nawata |
| collection | DOAJ |
| description | Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of antineutrophil cytoplasmic antibody-associated vasculitis. Patients often present with peripheral neuropathy and purpura, suggesting impairment of small vessels, especially capillaries. However, medium-sized vessels and small vessels with a vascular diameter larger than that of capillaries may also be impaired, causing atypical findings. We report a case of EGPA treated with corticosteroids, cyclophosphamide, and mepolizumab. Renal biopsy revealed vasculitis of the interlobular arteries as the cause of glomerulonephritis and interstitial nephritis. This case suggests the importance of considering vessels upstream of capillaries dominant EGPA as a differential diagnosis in patients with eosinophilia. |
| format | Article |
| id | doaj-art-bdf24aa3940c43eabf9b5320cf5b32e0 |
| institution | DOAJ |
| issn | 2090-6897 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-bdf24aa3940c43eabf9b5320cf5b32e02025-08-20T03:23:33ZengWileyCase Reports in Rheumatology2090-68972022-01-01202210.1155/2022/9606981Glomerulonephritis and Interstitial Nephritis Originating from Vasculitis of the Interlobular Arteries of the Kidney in a Patient with Eosinophilic Granulomatosis with PolyangiitisTakashi Nawata0Masaki Shibuya1Yukio Takeshita2Makoto Kubo3Noriko Uesugi4Masafumi Yano5Department of Medicine and Clinical ScienceDepartment of Medicine and Clinical ScienceDepartment of Neurology and Clinical NeuroscienceDepartment of Medicine and Clinical ScienceDepartment of PathologyDepartment of Medicine and Clinical ScienceEosinophilic granulomatosis with polyangiitis (EGPA) is a type of antineutrophil cytoplasmic antibody-associated vasculitis. Patients often present with peripheral neuropathy and purpura, suggesting impairment of small vessels, especially capillaries. However, medium-sized vessels and small vessels with a vascular diameter larger than that of capillaries may also be impaired, causing atypical findings. We report a case of EGPA treated with corticosteroids, cyclophosphamide, and mepolizumab. Renal biopsy revealed vasculitis of the interlobular arteries as the cause of glomerulonephritis and interstitial nephritis. This case suggests the importance of considering vessels upstream of capillaries dominant EGPA as a differential diagnosis in patients with eosinophilia.http://dx.doi.org/10.1155/2022/9606981 |
| spellingShingle | Takashi Nawata Masaki Shibuya Yukio Takeshita Makoto Kubo Noriko Uesugi Masafumi Yano Glomerulonephritis and Interstitial Nephritis Originating from Vasculitis of the Interlobular Arteries of the Kidney in a Patient with Eosinophilic Granulomatosis with Polyangiitis Case Reports in Rheumatology |
| title | Glomerulonephritis and Interstitial Nephritis Originating from Vasculitis of the Interlobular Arteries of the Kidney in a Patient with Eosinophilic Granulomatosis with Polyangiitis |
| title_full | Glomerulonephritis and Interstitial Nephritis Originating from Vasculitis of the Interlobular Arteries of the Kidney in a Patient with Eosinophilic Granulomatosis with Polyangiitis |
| title_fullStr | Glomerulonephritis and Interstitial Nephritis Originating from Vasculitis of the Interlobular Arteries of the Kidney in a Patient with Eosinophilic Granulomatosis with Polyangiitis |
| title_full_unstemmed | Glomerulonephritis and Interstitial Nephritis Originating from Vasculitis of the Interlobular Arteries of the Kidney in a Patient with Eosinophilic Granulomatosis with Polyangiitis |
| title_short | Glomerulonephritis and Interstitial Nephritis Originating from Vasculitis of the Interlobular Arteries of the Kidney in a Patient with Eosinophilic Granulomatosis with Polyangiitis |
| title_sort | glomerulonephritis and interstitial nephritis originating from vasculitis of the interlobular arteries of the kidney in a patient with eosinophilic granulomatosis with polyangiitis |
| url | http://dx.doi.org/10.1155/2022/9606981 |
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