The impact of rs6198 genotyping of glucocorticoid b-receptor gene in sepsis

The impact of rs6198 genotyping of glucocorticoid b-receptor gene in sepsis

BACKGROUND: Glucocorticosteroids (GCs) are used for the treatment of sepsis, while their role is mediated exclusively by the glucocorticoid receptor (GR) and its gene NR3C1. The rs6198 single-nucleotide polymorphism (SNP), localized in exon 9β of the NR3C1, has been shown to increase GC sensitivity....

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Bibliographic Details
Main Authors: Antonios Arapis, Georgia Damoraki, Dimitra Papatheodossiou, Stelios Apostolidis, Evangelos J Giamarellos Bourboulis
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
sepsis
glucocorticosteroids
ARDS
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716524003400
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