Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Promotes Hyperglycemia and Susceptibility to Streptozotocin-Induced Diabetes in Female Mice In Vivo

Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Promotes Hyperglycemia and Susceptibility to Streptozotocin-Induced Diabetes in Female Mice In Vivo

The development of type 2 diabetes (T2D) is largely dependent on the maintenance of pancreatic islet function and mass. Sexual dimorphism in T2D is evident in many areas, such as pathophysiology, treatment, and prevention. Mitogen-activated protein kinase phosphatase-2 (MKP-2) has a distinct role in...

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Bibliographic Details
Main Authors: Nabin Ghimire, Morgan Welch, Cassandra Secunda, Alexis Fink, Ahmed Lawan
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
hyperglycemia
diabetes
MKP-2
MAPK
islet
Online Access:https://www.mdpi.com/2073-4409/14/4/261
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