Surgical and radiological outcomes of giant cell tumor of the bone: prognostic value of Campanacci grading and selective use of denosumab

Surgical and radiological outcomes of giant cell tumor of the bone: prognostic value of Campanacci grading and selective use of denosumab

Abstract Background Advancements in diagnostic and therapeutic modalities for giant cell tumors of bone (GCTB) have introduced molecular and radiological tools that refine clinical decision-making. H3.3 G34W immunohistochemical staining has become a routine diagnostic marker, while H3F3A mutational...

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Bibliographic Details
Main Authors: Jasminka Igrec, Lisa Jernej, Maria Anna Smolle, Jakob Steiner, Susanne Scheipl, Birgit Lohberger, Andreas Leithner, Iva Brcic
Format: Article
Language:English
Published: SpringerOpen 2025-05-01
Series:Journal of Orthopaedics and Traumatology
Subjects:
Giant cell tumor of bone
Denosumab
H3.3
H3F3A
Radiological imaging
Online Access:https://doi.org/10.1186/s10195-025-00841-2
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