ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway
Gastric cancer is the fifth most common cancer and the fourth leading cause of cancer-related deaths worldwide, accounting for nearly 800,000 fatalities annually. ITGAX (Integrin alpha X) is closely associated with immune cells, such as macrophages and dendritic cells. Its involvement in gastric can...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1536478/full |
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| author | Jiali Hu Jing Cao Shanshan Huang Yang Chen Yang Chen |
| author_facet | Jiali Hu Jing Cao Shanshan Huang Yang Chen Yang Chen |
| author_sort | Jiali Hu |
| collection | DOAJ |
| description | Gastric cancer is the fifth most common cancer and the fourth leading cause of cancer-related deaths worldwide, accounting for nearly 800,000 fatalities annually. ITGAX (Integrin alpha X) is closely associated with immune cells, such as macrophages and dendritic cells. Its involvement in gastric cancer was identified through an analysis of The Gene Expression Omnibus (GEO) database, which highlighted ITGAX as one of four key gastric cancer-related genes. Our study demonstrates that ITGAX expression is significantly elevated in tumor tissues compared to normal tissues and is positively correlated with clinical prognosis in gastric cancer patients from the GEO database. Moreover, ITGAX enhanced cell proliferation, invasion, and tumorigenic capacity in mouse models. Furthermore, we explored the underlying role of ITGAX using Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein-protein interaction networks (PPI) analysis. Our findings reveal that ITGAX promotes gastric cancer progression by driving epithelial-mesenchymal transition pathway (EMT), suggesting its potential as a biomarker for early diagnosis and prognosis in gastric cancer. |
| format | Article |
| id | doaj-art-bddf2dcbd74f4d81adc5c2cceff9e447 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-bddf2dcbd74f4d81adc5c2cceff9e4472025-01-08T06:11:43ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15364781536478ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathwayJiali Hu0Jing Cao1Shanshan Huang2Yang Chen3Yang Chen4Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaSchool of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaGanjiang Chinese Medicine Innovation Center, Nanchang, ChinaKey Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, ChinaGastric cancer is the fifth most common cancer and the fourth leading cause of cancer-related deaths worldwide, accounting for nearly 800,000 fatalities annually. ITGAX (Integrin alpha X) is closely associated with immune cells, such as macrophages and dendritic cells. Its involvement in gastric cancer was identified through an analysis of The Gene Expression Omnibus (GEO) database, which highlighted ITGAX as one of four key gastric cancer-related genes. Our study demonstrates that ITGAX expression is significantly elevated in tumor tissues compared to normal tissues and is positively correlated with clinical prognosis in gastric cancer patients from the GEO database. Moreover, ITGAX enhanced cell proliferation, invasion, and tumorigenic capacity in mouse models. Furthermore, we explored the underlying role of ITGAX using Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein-protein interaction networks (PPI) analysis. Our findings reveal that ITGAX promotes gastric cancer progression by driving epithelial-mesenchymal transition pathway (EMT), suggesting its potential as a biomarker for early diagnosis and prognosis in gastric cancer.https://www.frontiersin.org/articles/10.3389/fphar.2024.1536478/fullITGAXgastric cancerEMTcell migrationtumorigenesis |
| spellingShingle | Jiali Hu Jing Cao Shanshan Huang Yang Chen Yang Chen ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway Frontiers in Pharmacology ITGAX gastric cancer EMT cell migration tumorigenesis |
| title | ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway |
| title_full | ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway |
| title_fullStr | ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway |
| title_full_unstemmed | ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway |
| title_short | ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway |
| title_sort | itgax promotes gastric cancer progression via epithelial mesenchymal transition pathway |
| topic | ITGAX gastric cancer EMT cell migration tumorigenesis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1536478/full |
| work_keys_str_mv | AT jialihu itgaxpromotesgastriccancerprogressionviaepithelialmesenchymaltransitionpathway AT jingcao itgaxpromotesgastriccancerprogressionviaepithelialmesenchymaltransitionpathway AT shanshanhuang itgaxpromotesgastriccancerprogressionviaepithelialmesenchymaltransitionpathway AT yangchen itgaxpromotesgastriccancerprogressionviaepithelialmesenchymaltransitionpathway AT yangchen itgaxpromotesgastriccancerprogressionviaepithelialmesenchymaltransitionpathway |