False-Positive HIV Testing in a Chimeric Antigen Receptor T-Cell Recipient: A Case Report
Chimeric antigen receptor T (CAR T) cell therapy has transformed the treatment of hematologic malignancies, and its use is rapidly expanding in other areas as well. Many currently available CAR T cells use a lentiviral vector derived from HIV-1, which can then lead to false -positive HIV tests in CA...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2024-12-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0621 |
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| Summary: | Chimeric antigen receptor T (CAR T) cell therapy has transformed the treatment of hematologic malignancies, and its use is rapidly expanding in other areas as well. Many currently available CAR T cells use a lentiviral vector derived from HIV-1, which can then lead to false -positive HIV tests in CAR T recipients. We present a case report and review of literature of this phenomenon. As increasing numbers of patients receive CAR T-cell therapy, awareness of the potential for false-positive HIV testing is critical for providing care to these patients. |
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| ISSN: | 2767-7664 |