Spot-Scanning Confocal Photon Beams for Hypofractionated Brain Radiosurgery
Introduction Stereotactic radiosurgery (SRS) has been broadly used to treat brain tumors. In this study, a dose kernel-based spot scanning (DKSC) treatment delivery has been developed for hypofractionated brain SRS. Methods DKSC treatments employs hundreds of confocal photon dose kernels. For such a...
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| Format: | Article |
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SAGE Publishing
2025-05-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338251342873 |
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| author | Lijun Ma PhD Shuang Luan PhD Nguyen Phuong Dang PhD Benjamin Ziemer PhD Steve Braunstein MD, PhD Michael McDermott MD Cheng Yu PhD Gabriel Zada MD Eric L Chang MD |
| author_facet | Lijun Ma PhD Shuang Luan PhD Nguyen Phuong Dang PhD Benjamin Ziemer PhD Steve Braunstein MD, PhD Michael McDermott MD Cheng Yu PhD Gabriel Zada MD Eric L Chang MD |
| author_sort | Lijun Ma PhD |
| collection | DOAJ |
| description | Introduction Stereotactic radiosurgery (SRS) has been broadly used to treat brain tumors. In this study, a dose kernel-based spot scanning (DKSC) treatment delivery has been developed for hypofractionated brain SRS. Methods DKSC treatments employs hundreds of confocal photon dose kernels. For such a delivery, a single continuous scanning path was first mapped within a 3D target volume, and then a series of dose kernels of variable sizes, shapes and beam weights were placed and then optimized along the path to produce highly conformal dose distributions. For implementation of DKSC delivery in a clinical setting, we specifically employed the Leksell Gamma Knife (LGK) system, where it is considered as the gold standard of modern SRS treatments. Results DKSC was successfully implemented for a patient treatment for the first time. General methodology as well as specific workflow and treatment planning caveats of implementing DKSC for the LGK is reported. To highlight the novelty of DKSC, we also compared DKSC against the conventional LGK-SRS treatment including its latest treatment planning optimization software. Conclusion DKSC has been demonstrated to be technically feasible, clinically implementable, and uniquely advantageous for hypofractionated brain SRS. Further studies are warranted toward testing DKSC for variable SRS modalities, different disease sites including extra-cranial lesions. |
| format | Article |
| id | doaj-art-bdd8a831f3ee439ab575fbf89593f4dc |
| institution | Kabale University |
| issn | 1533-0338 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SAGE Publishing |
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| series | Technology in Cancer Research & Treatment |
| spelling | doaj-art-bdd8a831f3ee439ab575fbf89593f4dc2025-08-20T03:47:33ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382025-05-012410.1177/15330338251342873Spot-Scanning Confocal Photon Beams for Hypofractionated Brain RadiosurgeryLijun Ma PhD0Shuang Luan PhD1Nguyen Phuong Dang PhD2Benjamin Ziemer PhD3Steve Braunstein MD, PhD4Michael McDermott MD5Cheng Yu PhD6Gabriel Zada MD7Eric L Chang MD8 , Los Angeles, CA, USA Department of Computer Science, University of New Mexico, Albuquerque, NM, USA , Los Angeles, CA, USA Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA , Los Angeles, CA, USA , Los Angeles, CA, USA , Los Angeles, CA, USAIntroduction Stereotactic radiosurgery (SRS) has been broadly used to treat brain tumors. In this study, a dose kernel-based spot scanning (DKSC) treatment delivery has been developed for hypofractionated brain SRS. Methods DKSC treatments employs hundreds of confocal photon dose kernels. For such a delivery, a single continuous scanning path was first mapped within a 3D target volume, and then a series of dose kernels of variable sizes, shapes and beam weights were placed and then optimized along the path to produce highly conformal dose distributions. For implementation of DKSC delivery in a clinical setting, we specifically employed the Leksell Gamma Knife (LGK) system, where it is considered as the gold standard of modern SRS treatments. Results DKSC was successfully implemented for a patient treatment for the first time. General methodology as well as specific workflow and treatment planning caveats of implementing DKSC for the LGK is reported. To highlight the novelty of DKSC, we also compared DKSC against the conventional LGK-SRS treatment including its latest treatment planning optimization software. Conclusion DKSC has been demonstrated to be technically feasible, clinically implementable, and uniquely advantageous for hypofractionated brain SRS. Further studies are warranted toward testing DKSC for variable SRS modalities, different disease sites including extra-cranial lesions.https://doi.org/10.1177/15330338251342873 |
| spellingShingle | Lijun Ma PhD Shuang Luan PhD Nguyen Phuong Dang PhD Benjamin Ziemer PhD Steve Braunstein MD, PhD Michael McDermott MD Cheng Yu PhD Gabriel Zada MD Eric L Chang MD Spot-Scanning Confocal Photon Beams for Hypofractionated Brain Radiosurgery Technology in Cancer Research & Treatment |
| title | Spot-Scanning Confocal Photon Beams for Hypofractionated Brain Radiosurgery |
| title_full | Spot-Scanning Confocal Photon Beams for Hypofractionated Brain Radiosurgery |
| title_fullStr | Spot-Scanning Confocal Photon Beams for Hypofractionated Brain Radiosurgery |
| title_full_unstemmed | Spot-Scanning Confocal Photon Beams for Hypofractionated Brain Radiosurgery |
| title_short | Spot-Scanning Confocal Photon Beams for Hypofractionated Brain Radiosurgery |
| title_sort | spot scanning confocal photon beams for hypofractionated brain radiosurgery |
| url | https://doi.org/10.1177/15330338251342873 |
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