NF-κB inhibition attenuates sympathetic hyperreflexia and concomitant development of autonomic dysreflexia and immune dysfunction after spinal cord injury

NF-κB inhibition attenuates sympathetic hyperreflexia and concomitant development of autonomic dysreflexia and immune dysfunction after spinal cord injury

Abstract Heightened sympathetic reflexes (sympathetic hyperreflexia, SH) post-high-level spinal cord injury (SCI) detrimentally impact effector organs, resulting in peripheral immune dysfunction and cardiovascular disease, two leading causes of morbidity and mortality in SCI. We previously found tha...

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Main Authors: Micaela L. O’Reilly, Mariah J. Wulf, Theresa M. Connors, Ying Jin, Frank Bearoff, Nan Hai, Julien Bouyer, Sandhya Kortagere, Yinghui Zhong, John R. Bethea, Veronica J. Tom
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08237-y
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