Fenbendazole induces pyroptosis in breast cancer cells through HK2/caspase-3/GSDME signaling pathway

Fenbendazole induces pyroptosis in breast cancer cells through HK2/caspase-3/GSDME signaling pathway

IntroductionPyroptosis, a gasdermin (GSDM) - mediated programmed cell death associated with inflammation, has emerged as a promising strategy for cancer therapy. Metabolic reprogramming, a hallmark of cancer, presents potential targets for malignancy intervention. Fenbendazole (FBZ), a safe and inex...

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Bibliographic Details
Main Authors: Tingting Pan, Shengqi Jin, Xiaoxia Huang, Xin Xin, Qiming Xing, Wenhui Yang, Jing Dong, Lin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
breast cancer
fenbendazole (FBZ)
pyroptosis
HK2
caspase-3
GSDME
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1596694/full
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