Inhibition of PDK modulates radiotherapy resistance in gastric cancer

Inhibition of PDK modulates radiotherapy resistance in gastric cancer

Abstract To explore the effect of sodium dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, on the progression of gastric cancer and resistance to radiotherapy, we analyzed histopathological microarrays from 60 gastric cancer and paracancerous tissues to determine PDK expression...

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Bibliographic Details
Main Authors: Qi Zhang, Wanjia Qiao, Xiaoyu Liu, Jun Lu, Farooq Benish, Shuping Li, Xiaojun Liu
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
Gastric cancer
DCA
PDK
Glycolysis
Radiotherapy resistance
Online Access:https://doi.org/10.1007/s12672-025-02635-8
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