The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study
Abstract Background The correlation between tumor-specific growth factor (TSGF) and the prognosis of colorectal cancer (CRC)has not been extensively studied. Research was designed to evaluate the potential of TSGF as a predictive marker for the prognosis of patients with CRC. Methods The serum TSGF...
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BMC
2025-04-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03902-2 |
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| author | Yanjun Lu Xinxuan Zhao Haiyi Liu Yixun Zhang Linghong Guo Lichun Wang |
| author_facet | Yanjun Lu Xinxuan Zhao Haiyi Liu Yixun Zhang Linghong Guo Lichun Wang |
| author_sort | Yanjun Lu |
| collection | DOAJ |
| description | Abstract Background The correlation between tumor-specific growth factor (TSGF) and the prognosis of colorectal cancer (CRC)has not been extensively studied. Research was designed to evaluate the potential of TSGF as a predictive marker for the prognosis of patients with CRC. Methods The serum TSGF was quantified and stratified into elevated/normal groups based on the established threshold detected using the rate method. The log-rank test was employed for survival analysis to evaluate the 3-year overall survival (OS). Prognostic independence was verified through Cox proportional hazards model. The receiver operating characteristic (ROC) curves were plotted to assess the clinical application value of TSGF. Results A total of 2223 patients were incorporated in our study. The survival analysis revealed that elevated TSGF levels were associated with poorer survival in CRC. The multivariate Cox analysis demonstrated TSGF as an independent prognostic factor. The signature covering TSGF with T staging, N staging, CEA, CA199 demonstrated superior predictive capability based on the Area Under the Curve (AUC) (Delong’s test p = 0.025). Conclusion TSGF is an independent factor correlating with the 3-year OS of stage I-III CRC patients. Moreover, our new signature including TSGF can effectively improve the prognostic evaluation of CRC, thereby contributing to precision medication. |
| format | Article |
| id | doaj-art-bdceaf6140734e44bdd7177d44f04865 |
| institution | OA Journals |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-bdceaf6140734e44bdd7177d44f048652025-08-20T02:19:58ZengBMCBMC Gastroenterology1471-230X2025-04-012511710.1186/s12876-025-03902-2The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation studyYanjun Lu0Xinxuan Zhao1Haiyi Liu2Yixun Zhang3Linghong Guo4Lichun Wang5Department of Colorectal Surgery, Cancer Hospital, Shanxi Province Cancer Hospital/Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Medical UniversityDepartment of Colorectal Surgery, Cancer Hospital, Shanxi Province Cancer Hospital/Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Medical UniversityDepartment of Colorectal Surgery, Cancer Hospital, Shanxi Province Cancer Hospital/Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Medical UniversityDepartment of Colorectal Surgery, Cancer Hospital, Shanxi Province Cancer Hospital/Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Medical UniversityDepartment of Colorectal Surgery, Cancer Hospital, Shanxi Province Cancer Hospital/Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Medical UniversityDepartment of Colorectal Surgery, Cancer Hospital, Shanxi Province Cancer Hospital/Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Medical UniversityAbstract Background The correlation between tumor-specific growth factor (TSGF) and the prognosis of colorectal cancer (CRC)has not been extensively studied. Research was designed to evaluate the potential of TSGF as a predictive marker for the prognosis of patients with CRC. Methods The serum TSGF was quantified and stratified into elevated/normal groups based on the established threshold detected using the rate method. The log-rank test was employed for survival analysis to evaluate the 3-year overall survival (OS). Prognostic independence was verified through Cox proportional hazards model. The receiver operating characteristic (ROC) curves were plotted to assess the clinical application value of TSGF. Results A total of 2223 patients were incorporated in our study. The survival analysis revealed that elevated TSGF levels were associated with poorer survival in CRC. The multivariate Cox analysis demonstrated TSGF as an independent prognostic factor. The signature covering TSGF with T staging, N staging, CEA, CA199 demonstrated superior predictive capability based on the Area Under the Curve (AUC) (Delong’s test p = 0.025). Conclusion TSGF is an independent factor correlating with the 3-year OS of stage I-III CRC patients. Moreover, our new signature including TSGF can effectively improve the prognostic evaluation of CRC, thereby contributing to precision medication.https://doi.org/10.1186/s12876-025-03902-2Colorectal cancerTumor-specific growth factorPrognosis |
| spellingShingle | Yanjun Lu Xinxuan Zhao Haiyi Liu Yixun Zhang Linghong Guo Lichun Wang The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study BMC Gastroenterology Colorectal cancer Tumor-specific growth factor Prognosis |
| title | The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study |
| title_full | The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study |
| title_fullStr | The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study |
| title_full_unstemmed | The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study |
| title_short | The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study |
| title_sort | prognostic significance of tumor specific growth factor in colorectal cancer an observation study |
| topic | Colorectal cancer Tumor-specific growth factor Prognosis |
| url | https://doi.org/10.1186/s12876-025-03902-2 |
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