Availability of olfactory bulb: experience from a British Brain Bank
The olfactory bulb and tract (OB/OT) are among the earliest structures in the brain to undergo pathological changes in many neurodegenerative conditions. The availability of OB/OT samples from brain specimens in brain banks therefore assumes importance. We collected data from 5 years (2006-2010) reg...
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Thieme Revinter Publicações
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000200010&lng=en&tlng=en |
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| author | Suraj Rajan Linda Parsons Andrew J Lees Laura Silveira-Moriyama |
| author_facet | Suraj Rajan Linda Parsons Andrew J Lees Laura Silveira-Moriyama |
| author_sort | Suraj Rajan |
| collection | DOAJ |
| description | The olfactory bulb and tract (OB/OT) are among the earliest structures in the brain to undergo pathological changes in many neurodegenerative conditions. The availability of OB/OT samples from brain specimens in brain banks therefore assumes importance. We collected data from 5 years (2006-2010) regarding the presence or absence of OB/OT material in cases received by the Queen Square Brain Bank (QSBB) for Neurological Disorders, UCL Institute of Neurology, UK, to estimate availability of OB/OT material at the brain bank and also to look for possible associations. Of the 438 cases received, 320 had complete data regarding OB/OT and 29.4% of these had OB/OT in at least one half of the specimen. Unavailability of OB/OT was associated with larger post-mortem delays (p<0.001), suggesting that the delay might render the tissue more friable and hence lead to its loss. Brains from female donors also tended to have a higher availability in our samples. |
| format | Article |
| id | doaj-art-bdc6025621bf4e7dadee1e49f34274f0 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-bdc6025621bf4e7dadee1e49f34274f02025-08-20T03:04:45ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-4227712110112S0004-282X2013000200010Availability of olfactory bulb: experience from a British Brain BankSuraj Rajan0Linda Parsons1Andrew J Lees2Laura Silveira-Moriyama3University College LondonUniversity College LondonUniversity College LondonUniversity College LondonThe olfactory bulb and tract (OB/OT) are among the earliest structures in the brain to undergo pathological changes in many neurodegenerative conditions. The availability of OB/OT samples from brain specimens in brain banks therefore assumes importance. We collected data from 5 years (2006-2010) regarding the presence or absence of OB/OT material in cases received by the Queen Square Brain Bank (QSBB) for Neurological Disorders, UCL Institute of Neurology, UK, to estimate availability of OB/OT material at the brain bank and also to look for possible associations. Of the 438 cases received, 320 had complete data regarding OB/OT and 29.4% of these had OB/OT in at least one half of the specimen. Unavailability of OB/OT was associated with larger post-mortem delays (p<0.001), suggesting that the delay might render the tissue more friable and hence lead to its loss. Brains from female donors also tended to have a higher availability in our samples.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000200010&lng=en&tlng=enolfactory bulbolfactory tractbrain bankautopsyParkinson's disease |
| spellingShingle | Suraj Rajan Linda Parsons Andrew J Lees Laura Silveira-Moriyama Availability of olfactory bulb: experience from a British Brain Bank Arquivos de Neuro-Psiquiatria olfactory bulb olfactory tract brain bank autopsy Parkinson's disease |
| title | Availability of olfactory bulb: experience from a British Brain Bank |
| title_full | Availability of olfactory bulb: experience from a British Brain Bank |
| title_fullStr | Availability of olfactory bulb: experience from a British Brain Bank |
| title_full_unstemmed | Availability of olfactory bulb: experience from a British Brain Bank |
| title_short | Availability of olfactory bulb: experience from a British Brain Bank |
| title_sort | availability of olfactory bulb experience from a british brain bank |
| topic | olfactory bulb olfactory tract brain bank autopsy Parkinson's disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000200010&lng=en&tlng=en |
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