ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE
Chronic heart failure (CHF) is one of the prognostic complications of essential hypertension (EH), which is the most common non-communicable disease in the world. The aim of the study is to improve the effectiveness of diagnosis of EH progression based on cluster analysis, which is based on anthropo...
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| Format: | Article |
| Language: | English |
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Poltava State Medical University
2020-12-01
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| Series: | Проблеми екології та медицини |
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| Online Access: | https://ecomed-journal.org/index.php/journal/article/view/197 |
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| author | M.O. Matokhniuk I.P. Pashkova V. M. Zhebel |
| author_facet | M.O. Matokhniuk I.P. Pashkova V. M. Zhebel |
| author_sort | M.O. Matokhniuk |
| collection | DOAJ |
| description | Chronic heart failure (CHF) is one of the prognostic complications of essential hypertension (EH), which is the most common non-communicable disease in the world. The aim of the study is to improve the effectiveness of diagnosis of EH progression based on cluster analysis, which is based on anthropometric, laboratory and systemic and intracardiac hemodynamics in men 40-60 years. The study included 50 men with asymptomatic EH aged 50.62 ± 0.73 years and 50 men with EH complicated by CHF aged 51.86 ± 0.81 years. All participants underwent standard cardio-graphic examinations, the plasma concentration of cardiotrophin-1 (CT-1) in the blood was determined by enzyme-linked immunosorbent assay (ELISA) and rs8046707 of the CT-1 gene in venous blood samples using the PLR method. The phenotypic portrait of the patient was distinguished by cluster analysis. |
| format | Article |
| id | doaj-art-bdbe6723f9fa44458c7ecd880396977d |
| institution | OA Journals |
| issn | 2073-4662 2519-2302 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Poltava State Medical University |
| record_format | Article |
| series | Проблеми екології та медицини |
| spelling | doaj-art-bdbe6723f9fa44458c7ecd880396977d2025-08-20T02:19:12ZengPoltava State Medical UniversityПроблеми екології та медицини2073-46622519-23022020-12-01245-6141610.31718/mep.2020.24.5-6.04197ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENEM.O. Matokhniuk0I.P. Pashkova1V. M. Zhebel2Vinnytsia National Pirogov Memorial Medical UniversityVinnytsia National Pirogov Memorial Medical UniversityVinnytsia National Pirogov Memorial Medical UniversityChronic heart failure (CHF) is one of the prognostic complications of essential hypertension (EH), which is the most common non-communicable disease in the world. The aim of the study is to improve the effectiveness of diagnosis of EH progression based on cluster analysis, which is based on anthropometric, laboratory and systemic and intracardiac hemodynamics in men 40-60 years. The study included 50 men with asymptomatic EH aged 50.62 ± 0.73 years and 50 men with EH complicated by CHF aged 51.86 ± 0.81 years. All participants underwent standard cardio-graphic examinations, the plasma concentration of cardiotrophin-1 (CT-1) in the blood was determined by enzyme-linked immunosorbent assay (ELISA) and rs8046707 of the CT-1 gene in venous blood samples using the PLR method. The phenotypic portrait of the patient was distinguished by cluster analysis.https://ecomed-journal.org/index.php/journal/article/view/197essential hypertension, chronic heart failure, cardiotrophin-1. |
| spellingShingle | M.O. Matokhniuk I.P. Pashkova V. M. Zhebel ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE Проблеми екології та медицини essential hypertension, chronic heart failure, cardiotrophin-1. |
| title | ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE |
| title_full | ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE |
| title_fullStr | ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE |
| title_full_unstemmed | ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE |
| title_short | ENGLISH VERSION:PHENOTYPIC PORTRAIT OF ESSENTIAL HYPERTENSION AS A TOOL TO INCREASE THE EFFICIENCY OF ITS DIAGNOSIS AND PROGRESSION IN MEN WITH POLYMORPHIC VARIANTS OF THE CARDIOTROPHIN-1 GENE |
| title_sort | english version phenotypic portrait of essential hypertension as a tool to increase the efficiency of its diagnosis and progression in men with polymorphic variants of the cardiotrophin 1 gene |
| topic | essential hypertension, chronic heart failure, cardiotrophin-1. |
| url | https://ecomed-journal.org/index.php/journal/article/view/197 |
| work_keys_str_mv | AT momatokhniuk englishversionphenotypicportraitofessentialhypertensionasatooltoincreasetheefficiencyofitsdiagnosisandprogressioninmenwithpolymorphicvariantsofthecardiotrophin1gene AT ippashkova englishversionphenotypicportraitofessentialhypertensionasatooltoincreasetheefficiencyofitsdiagnosisandprogressioninmenwithpolymorphicvariantsofthecardiotrophin1gene AT vmzhebel englishversionphenotypicportraitofessentialhypertensionasatooltoincreasetheefficiencyofitsdiagnosisandprogressioninmenwithpolymorphicvariantsofthecardiotrophin1gene |