Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases
Introduction: Oxidative stress is an important component in the pathogenesis of Alzheimer’s disease (AD). Materils and Methods: A comparative cross-sectional study was conducted on 140 participants who made up 70 subjects diagnosed with AD and 70 controls. Serum levels of F2-isoprostanes and Preseni...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1786_24 |
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| author | Dilip Raj Timalsina Leela Abichandani Ranjit Ambad |
| author_facet | Dilip Raj Timalsina Leela Abichandani Ranjit Ambad |
| author_sort | Dilip Raj Timalsina |
| collection | DOAJ |
| description | Introduction:
Oxidative stress is an important component in the pathogenesis of Alzheimer’s disease (AD).
Materils and Methods:
A comparative cross-sectional study was conducted on 140 participants who made up 70 subjects diagnosed with AD and 70 controls. Serum levels of F2-isoprostanes and Presenilin 1 were estimated using ELISA. These markers were significantly elevated in the serum of AD patients, suggesting them to be potential biomarkers for early diagnosis and disease progression.
Aim and Objective:
In this study, the level of F2-isoprostanes and Presenilin 1 was determined in patients clinically diagnosed with AD, thus establishing a possible relationship between heightened markers for oxidative stress and progression of AD.
Results:
The results showed significantly elevated levels of F2-isoprostanes (179.38 ± 3.01 pg/mL vs 85.89 ± 0.97 pg/mL, P < 0.0001) and Presenilin 1 (93.26 ± 2.39 ng/mL vs 49.46 ± 0.78 ng/mL, P < 0.0001) in AD patients compared to controls. Additionally, markers of lipid peroxidation, such as malondialdehyde (MDA), were elevated in AD patients, while antioxidant defense mechanisms, including glutathione (GSH) and superoxide dismutase (SOD), were significantly impaired (P < 0.0001).
Conclusion:
This study provides compelling evidence that oxidative stress, as shown by elevated levels of F2-isoprostanes and Presenilin 1, plays a crucial role in the onset of AD. |
| format | Article |
| id | doaj-art-bdbb38ce21ff400ca281a1993c6a8db2 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-bdbb38ce21ff400ca281a1993c6a8db22025-08-20T03:24:42ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S384S38710.4103/jpbs.jpbs_1786_24Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s DiseasesDilip Raj TimalsinaLeela AbichandaniRanjit AmbadIntroduction: Oxidative stress is an important component in the pathogenesis of Alzheimer’s disease (AD). Materils and Methods: A comparative cross-sectional study was conducted on 140 participants who made up 70 subjects diagnosed with AD and 70 controls. Serum levels of F2-isoprostanes and Presenilin 1 were estimated using ELISA. These markers were significantly elevated in the serum of AD patients, suggesting them to be potential biomarkers for early diagnosis and disease progression. Aim and Objective: In this study, the level of F2-isoprostanes and Presenilin 1 was determined in patients clinically diagnosed with AD, thus establishing a possible relationship between heightened markers for oxidative stress and progression of AD. Results: The results showed significantly elevated levels of F2-isoprostanes (179.38 ± 3.01 pg/mL vs 85.89 ± 0.97 pg/mL, P < 0.0001) and Presenilin 1 (93.26 ± 2.39 ng/mL vs 49.46 ± 0.78 ng/mL, P < 0.0001) in AD patients compared to controls. Additionally, markers of lipid peroxidation, such as malondialdehyde (MDA), were elevated in AD patients, while antioxidant defense mechanisms, including glutathione (GSH) and superoxide dismutase (SOD), were significantly impaired (P < 0.0001). Conclusion: This study provides compelling evidence that oxidative stress, as shown by elevated levels of F2-isoprostanes and Presenilin 1, plays a crucial role in the onset of AD.https://journals.lww.com/10.4103/jpbs.jpbs_1786_24glutathione (gsh)lipid peroxidationmalondialdehyde (mda)neurodegenerationsuperoxide dismutase (sod) |
| spellingShingle | Dilip Raj Timalsina Leela Abichandani Ranjit Ambad Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases Journal of Pharmacy and Bioallied Sciences glutathione (gsh) lipid peroxidation malondialdehyde (mda) neurodegeneration superoxide dismutase (sod) |
| title | Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases |
| title_full | Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases |
| title_fullStr | Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases |
| title_full_unstemmed | Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases |
| title_short | Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases |
| title_sort | role of oxidative stress markers f2 isoprostanes and presenilin 1 in clinical diagnosed alzheimer s diseases |
| topic | glutathione (gsh) lipid peroxidation malondialdehyde (mda) neurodegeneration superoxide dismutase (sod) |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1786_24 |
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