Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical Trial
Background: Taurine (Tau) is naturally synthesized in the body from cysteine. It plays a crucial role in lipid and carbohydrate metabolism, increasing energy consumption, reducing inflammation, and controlling appetite. Some research suggests that obesity may be associated with decreased serum Tau l...
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Shahid Sadoughi University of Medical Sciences and Health Services
2025-02-01
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| Series: | Journal of Nutrition and Food Security |
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| Online Access: | http://jnfs.ssu.ac.ir/article-1-887-en.pdf |
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| author | Maryam Asadi Fatemeh Haidari Hossein Bavi Behbahani Maryam J Chitsazi Javad Mohammadi-asl Kambiz Ahmadi-Angali |
| author_facet | Maryam Asadi Fatemeh Haidari Hossein Bavi Behbahani Maryam J Chitsazi Javad Mohammadi-asl Kambiz Ahmadi-Angali |
| author_sort | Maryam Asadi |
| collection | DOAJ |
| description | Background: Taurine (Tau) is naturally synthesized in the body from cysteine. It plays a crucial role in lipid and carbohydrate metabolism, increasing energy consumption, reducing inflammation, and controlling appetite. Some research suggests that obesity may be associated with decreased serum Tau levels. This study is the first randomized controlled trial to assess the effectiveness of a Tau supplement in combination with a weight loss intervention on fibroblast growth factors (FGF) 19, 21, and β-Klotho co-receptor in obese women. Methods: Participants were randomly assigned to two groups: a standard weight-loss group receiving 3 g/day of Tau capsules for 8 weeks (n=20) and a standard weight-loss group receiving placebo capsules for 8 weeks (n=18). The weight loss intervention aimed to reduce 30% of the total energy consumed by the participants.A paired t-test and an independent sample t-test were employed to assess parametric continuous data within and between the groups. Analysis of covariance was utilized to control for confounding variables. Results: At post-intervention, there was a significant reduction in mean changes of β-Klotho (P=0.01) in Tau group, compared to the control group. However, there were no significant differences in mean changes of FGF 19 and FGF 21 between the two groups (P>0.05). Conclusion:This study suggests that Tau supplementation alongside a weight loss diet may lead to a reduction in serum levels ofβ-Klothoco-receptor, which could serve as an alternative marker of obesity. |
| format | Article |
| id | doaj-art-bdb0bfccc5514859a3732f0da7682d6b |
| institution | Kabale University |
| issn | 2476-7417 2476-7425 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Shahid Sadoughi University of Medical Sciences and Health Services |
| record_format | Article |
| series | Journal of Nutrition and Food Security |
| spelling | doaj-art-bdb0bfccc5514859a3732f0da7682d6b2025-02-08T10:57:36ZengShahid Sadoughi University of Medical Sciences and Health ServicesJournal of Nutrition and Food Security2476-74172476-74252025-02-01101103112Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical TrialMaryam Asadi0Fatemeh Haidari1Hossein Bavi Behbahani2Maryam J Chitsazi3Javad Mohammadi-asl4Kambiz Ahmadi-Angali5 Department of Nutrition, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran School of Health, Medical and Applies Sciences, CQ University, Brisbane, Australia Student Research Committee, Ahvaz Junishapur University of Medical Sciences, Ahvaz, Iran Nutrition and Food Security Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Background: Taurine (Tau) is naturally synthesized in the body from cysteine. It plays a crucial role in lipid and carbohydrate metabolism, increasing energy consumption, reducing inflammation, and controlling appetite. Some research suggests that obesity may be associated with decreased serum Tau levels. This study is the first randomized controlled trial to assess the effectiveness of a Tau supplement in combination with a weight loss intervention on fibroblast growth factors (FGF) 19, 21, and β-Klotho co-receptor in obese women. Methods: Participants were randomly assigned to two groups: a standard weight-loss group receiving 3 g/day of Tau capsules for 8 weeks (n=20) and a standard weight-loss group receiving placebo capsules for 8 weeks (n=18). The weight loss intervention aimed to reduce 30% of the total energy consumed by the participants.A paired t-test and an independent sample t-test were employed to assess parametric continuous data within and between the groups. Analysis of covariance was utilized to control for confounding variables. Results: At post-intervention, there was a significant reduction in mean changes of β-Klotho (P=0.01) in Tau group, compared to the control group. However, there were no significant differences in mean changes of FGF 19 and FGF 21 between the two groups (P>0.05). Conclusion:This study suggests that Tau supplementation alongside a weight loss diet may lead to a reduction in serum levels ofβ-Klothoco-receptor, which could serve as an alternative marker of obesity.http://jnfs.ssu.ac.ir/article-1-887-en.pdftaurinecalorie restrictionweight loss programfibroblast growth factorsβ-klothoobesity. |
| spellingShingle | Maryam Asadi Fatemeh Haidari Hossein Bavi Behbahani Maryam J Chitsazi Javad Mohammadi-asl Kambiz Ahmadi-Angali Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical Trial Journal of Nutrition and Food Security taurine calorie restriction weight loss program fibroblast growth factors β-klotho obesity. |
| title | Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical Trial |
| title_full | Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical Trial |
| title_fullStr | Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical Trial |
| title_full_unstemmed | Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical Trial |
| title_short | Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical Trial |
| title_sort | effect of weight loss diet combined with taurine supplementation on fasting levels of fibroblast growth factors19 21 and 𝛃 klothoco receptor in obese women a randomized clinical trial |
| topic | taurine calorie restriction weight loss program fibroblast growth factors β-klotho obesity. |
| url | http://jnfs.ssu.ac.ir/article-1-887-en.pdf |
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