Evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism: A systematic review and meta-analysis
Objective To systematically assess the efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism. Methods A data search was done on CBM, CNKI, VIP, PubMed/Medline, Cochrane Library, Web of Science, Embase and Wan Fang databases, so as to find studies from database...
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Editorial Department of Journal of Clinical Nephrology
2019-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | XIONG Huai-yu HUANG Qiang-ru YAN Pei-jing SHUAI Tian-kui LIU Jing-jing ZHU Lei LU Jia-ju YANG Ke-hu LIU Jian |
| author_facet | XIONG Huai-yu HUANG Qiang-ru YAN Pei-jing SHUAI Tian-kui LIU Jing-jing ZHU Lei LU Jia-ju YANG Ke-hu LIU Jian |
| author_sort | XIONG Huai-yu |
| collection | DOAJ |
| description | Objective To systematically assess the efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism. Methods A data search was done on CBM, CNKI, VIP, PubMed/Medline, Cochrane Library, Web of Science, Embase and Wan Fang databases, so as to find studies from database development up to 18<sup>th</sup>-Jan-2019 that use the levothyroxine to treat patients who were diagnosed as nephrotic syndrome（NS） with hypothyroidism. Two researchers retrieved the data and extracted studies separately. Data analysis was done by Stata software. Results A total 16 studies were included, which contained 826 patients. The results about meta-analysis were: in the first two months of treatment with levothyroxine tablets, there was no significant difference in the improvement effect between the two groups. After more than 3 months, the left thyroxine tablets group had higher remission rate than the untreated group（1 month:RR=2.03, 95%CI 0.41～9.97, P=0.107; 2 months: RR=1.43, 95%CI 0.85～2.43, P=0.181; 3 months: RR=1.59, 95%CI 1.36～1.86, P<0.01; 6 months: RR=1.53, 95%CI 1.32～1.77, P<0.01; 12 months: RR=1.34, 95%CI 1.11～1.63, P<0.001）. Comparisons between the treatment group and the control group, in increase magnitude in the level of FT3（SMD=2.29, 95%CI 1.58～3.00, P<0.01）, the level of urinary protein（WMD=-1.21 g/L, 95%CI-2.19～-0.22, P<0.01） and the edema elimination rate（WMD=-10.55 d,95%CI-12.53～-8.56,P<0.01）, showed statistically significant differences. The difference in the time for negative transformation of urinary protein between the two groups were not statistically significant（SMD=-2.05, 95%CI-4.20～0.10, P=0.062）. Conclusions Treatment with levothyroxine in patients with NS and hypothyroidism can reduce the burden on the kidneys, accelerate the recovery of thyroid function, and promote a good prognosis. |
| format | Article |
| id | doaj-art-bdaff7092abf4959949c841e4088f90f |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2019-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-bdaff7092abf4959949c841e4088f90f2025-08-20T03:52:51ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902019-01-011974875457911862Evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism: A systematic review and meta-analysisXIONG Huai-yuHUANG Qiang-ruYAN Pei-jingSHUAI Tian-kuiLIU Jing-jingZHU LeiLU Jia-juYANG Ke-huLIU JianObjective To systematically assess the efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism. Methods A data search was done on CBM, CNKI, VIP, PubMed/Medline, Cochrane Library, Web of Science, Embase and Wan Fang databases, so as to find studies from database development up to 18<sup>th</sup>-Jan-2019 that use the levothyroxine to treat patients who were diagnosed as nephrotic syndrome（NS） with hypothyroidism. Two researchers retrieved the data and extracted studies separately. Data analysis was done by Stata software. Results A total 16 studies were included, which contained 826 patients. The results about meta-analysis were: in the first two months of treatment with levothyroxine tablets, there was no significant difference in the improvement effect between the two groups. After more than 3 months, the left thyroxine tablets group had higher remission rate than the untreated group（1 month:RR=2.03, 95%CI 0.41～9.97, P=0.107; 2 months: RR=1.43, 95%CI 0.85～2.43, P=0.181; 3 months: RR=1.59, 95%CI 1.36～1.86, P<0.01; 6 months: RR=1.53, 95%CI 1.32～1.77, P<0.01; 12 months: RR=1.34, 95%CI 1.11～1.63, P<0.001）. Comparisons between the treatment group and the control group, in increase magnitude in the level of FT3（SMD=2.29, 95%CI 1.58～3.00, P<0.01）, the level of urinary protein（WMD=-1.21 g/L, 95%CI-2.19～-0.22, P<0.01） and the edema elimination rate（WMD=-10.55 d,95%CI-12.53～-8.56,P<0.01）, showed statistically significant differences. The difference in the time for negative transformation of urinary protein between the two groups were not statistically significant（SMD=-2.05, 95%CI-4.20～0.10, P=0.062）. Conclusions Treatment with levothyroxine in patients with NS and hypothyroidism can reduce the burden on the kidneys, accelerate the recovery of thyroid function, and promote a good prognosis.http://www.lcszb.com/thesisDetails?columnId=57911862&Fpath=home&index=0Nephrotic syndromeHypothyroidismLevothyroxineSystematic review |
| spellingShingle | XIONG Huai-yu HUANG Qiang-ru YAN Pei-jing SHUAI Tian-kui LIU Jing-jing ZHU Lei LU Jia-ju YANG Ke-hu LIU Jian Evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism: A systematic review and meta-analysis Linchuang shenzangbing zazhi Nephrotic syndrome Hypothyroidism Levothyroxine Systematic review |
| title | Evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism: A systematic review and meta-analysis |
| title_full | Evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism: A systematic review and meta-analysis |
| title_fullStr | Evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism: A systematic review and meta-analysis |
| title_full_unstemmed | Evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism: A systematic review and meta-analysis |
| title_short | Evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism: A systematic review and meta-analysis |
| title_sort | evaluation of efficacy of levothyroxine tablets in the treatment of nephrotic syndrome with hypothyroidism a systematic review and meta analysis |
| topic | Nephrotic syndrome Hypothyroidism Levothyroxine Systematic review |
| url | http://www.lcszb.com/thesisDetails?columnId=57911862&Fpath=home&index=0 |
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