Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Although many therapeutic modalities have been established for treating HCC patients, the outcomes of patients remain unsatisfactory. Development of independent prognostic biomarkers is thus an im...
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| Format: | Article |
| Language: | English |
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Springer
2025-03-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02043-y |
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| author | Long-Bin Jeng Wen-Ling Chan Chiao-Fang Teng |
| author_facet | Long-Bin Jeng Wen-Ling Chan Chiao-Fang Teng |
| author_sort | Long-Bin Jeng |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Although many therapeutic modalities have been established for treating HCC patients, the outcomes of patients remain unsatisfactory. Development of independent prognostic biomarkers is thus an important need to allow for early diagnosis and timely treatment. MicroRNAs (miRNAs) are the most studied class of small non-coding RNAs. It has been shown that miRNAs play essential roles in the multiple steps of HCC tumorigenesis and progression. Furthermore, the baseline expression levels of many miRNAs are altered in tumor tissues and blood circulation of HCC patients. Therefore, miRNAs have emerged as independent biomarkers for the prediction of HCC prognosis. This review provides a comprehensive literature-based summary of tissue and circulating miRNA biomarkers with independent prognostic significance in HCC. |
| format | Article |
| id | doaj-art-bdacb538945f41cd9e253372af94d2c0 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-bdacb538945f41cd9e253372af94d2c02025-08-20T02:59:57ZengSpringerDiscover Oncology2730-60112025-03-011611910.1007/s12672-025-02043-yIndependent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinomaLong-Bin Jeng0Wen-Ling Chan1Chiao-Fang Teng2Organ Transplantation Center, China Medical University HospitalDepartment of Public Health, College of Public Health, China Medical UniversityOrgan Transplantation Center, China Medical University HospitalAbstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Although many therapeutic modalities have been established for treating HCC patients, the outcomes of patients remain unsatisfactory. Development of independent prognostic biomarkers is thus an important need to allow for early diagnosis and timely treatment. MicroRNAs (miRNAs) are the most studied class of small non-coding RNAs. It has been shown that miRNAs play essential roles in the multiple steps of HCC tumorigenesis and progression. Furthermore, the baseline expression levels of many miRNAs are altered in tumor tissues and blood circulation of HCC patients. Therefore, miRNAs have emerged as independent biomarkers for the prediction of HCC prognosis. This review provides a comprehensive literature-based summary of tissue and circulating miRNA biomarkers with independent prognostic significance in HCC.https://doi.org/10.1007/s12672-025-02043-yHepatocellular carcinomaMicroRNATissueCirculatingPrognostic biomarker |
| spellingShingle | Long-Bin Jeng Wen-Ling Chan Chiao-Fang Teng Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma Discover Oncology Hepatocellular carcinoma MicroRNA Tissue Circulating Prognostic biomarker |
| title | Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma |
| title_full | Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma |
| title_fullStr | Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma |
| title_full_unstemmed | Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma |
| title_short | Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma |
| title_sort | independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma |
| topic | Hepatocellular carcinoma MicroRNA Tissue Circulating Prognostic biomarker |
| url | https://doi.org/10.1007/s12672-025-02043-y |
| work_keys_str_mv | AT longbinjeng independentprognosticsignificanceoftissueandcirculatingmicrornabiomarkersinhepatocellularcarcinoma AT wenlingchan independentprognosticsignificanceoftissueandcirculatingmicrornabiomarkersinhepatocellularcarcinoma AT chiaofangteng independentprognosticsignificanceoftissueandcirculatingmicrornabiomarkersinhepatocellularcarcinoma |