THE NATURE OF VASCULAR LESIONS AND SENSITIVITY TO HYPOTENSIVE TREATMENT IN PATIENTS WITH ARTERIAL HYPERTENSION WITH OBESITY AND BASELINE HYPERINSULINEMIA
We have studied the incidence of vascular lesions in coronary, cerebral, renal and peripheral arteries and estimated sensitivity to hypotensive treatment with ACE inhibitor Enam and calcium antagonist amlodipine in 372 patients in order to19 Евсиков Е.М. - Характер сосудистых поражений и чувствитель...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2001-02-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2162 |
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| Summary: | We have studied the incidence of vascular lesions in coronary, cerebral, renal and peripheral arteries and estimated sensitivity to hypotensive treatment with ACE inhibitor Enam and calcium antagonist amlodipine in 372 patients in order to19 Евсиков Е.М. - Характер сосудистых поражений и чувствительнось к гипотензивной determine the influence of obesity and baseline hyperinsulinemia on the mechanisms of arterial hypertension development and progression.We have divided 372 patients (153 men and 219 women, aged 21-22) with chronic mild to severe (WHO classification 1996) arterial hypertension into 2 groups: 118 patients with mild to moderate hypertension and obesity (BMI ranging from 36 to 67) and baseline hyperinsulinemia (25-119 mIU/mL) and those without obesity and baseline hyperinsulinemia. The nature and frequency of the lesions were assessed by instrumental means including angiographic confirmation in part of the patients. We have determined the incidence of angina and coronary lesions in obese patients is higher in young age already, with the predominance of coronary, cerebral and peripheral form of vascular lesions becoming statistically significant after the threshold of 50 years. Decreased sensitivity to the hypotensive action of an ACE inhibitor enalapril and increased – to treatment by amlodipine, a calcium antagonist, was observed in obese patients. |
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| ISSN: | 1560-4071 2618-7620 |