Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study.

Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study.

Imputation has been widely used in genome-wide association studies (GWAS) to infer genotypes of un-genotyped variants based on the linkage disequilibrium in external reference panels such as the HapMap and 1000 Genomes. However, imputation has only rarely been performed based on family relationships...

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Bibliographic Details
Main Authors: Ming-Huei Chen, Jie Huang, Wei-Min Chen, Martin G Larson, Caroline S Fox, Ramachandran S Vasan, Sudha Seshadri, Christopher J O'Donnell, Qiong Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051589&type=printable
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